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Diet Pro - Unlock the Key to Long Term Successful Weight Loss Dietary carbohydrates (grains, starches, and sugars) trigger insulin increase which in turn leads to Syndrome X, a common condition of aging that includes weight gain, mental fogginess, increased risk of heart disease and more. Our new Diet Pro formula is designed with advanced nutrients to help prevent and reverse the negative effects of dietary carbohydrates- by slowing carbohydrate absorption and improving insulin regulation in your body. Syndrome X Syndrome X - sounds like something from a science fiction movie doesn’t it? In fact, Syndrome X is a very real condition that affects the lives of huge numbers of people. It’s estimated that around 1 in 5 people are living with Syndrome X with research suggesting that the prevalence in the United States may be as high as 25% (or 1 in 4) of the population(1). And yet most of us have probably never even heard of the condition before. And what’s more if you are one of the millions of people who have tried to lose weight but without any success then maybe Syndrome X is the reason that you can’t succeed. In fact, Syndrome X is the most common reason why people can’t lose weight especially as they get older. So just what is Syndrome X? Syndrome X is a combination of medical disorders that increase the risk of developing cardiovascular disease and Type 2 (adult onset) diabetes. Confusingly Syndrome X is also known by a number of other different names - metabolic syndrome, metabolic Syndrome X, Reaven’s syndrome, insulin resistance syndrome and, in Australia, CHAOS. What disorders have to be present for a diagnosis of Syndrome X to be made? These days we’re all too well aware that there are a cluster of symptoms (risk factors) that are strongly associated with the risk of developing of Type 2 diabetes and cardiovascular diseases such as heart attack and stroke. These medical disorders include such things as high blood pressure, high cholesterol and having an ‘apple body shape’ i.e. carrying excess weight around the waist. Various associations between the risk factors were first noted as far back as the 1920’s. By the 1950’s the term metabolic syndrome (a.k.a. Syndrome X) had started to be used to describe the combination of these disorders but it was not until the 1988 that term Syndrome X was coined by Stanford medical researcher Dr. Gerald Reaven. Nowadays we understand that the symptoms of Syndrome X include: •Fatigue •Central obesity - also known as visceral, male-pattern or apple-shaped adiposity, colloquially this type of weight gain is often referred to as being ‘pot-bellied’ or as having a ‘beer belly’ •Difficulty in losing weight •Coronary heart disease - around 50% of patients with coronary heart disease suffer from Syndrome X and people with Syndrome X are around 3 times more likely to die from cardiovascular disease even after other risk factors have been controlled(2) •Heart palpitations •High blood pressure (hypertension) •High cholesterol (hypercholesterolemia) - especially raised LDL cholesterol and low HDL cholesterol •Elevated triglyceride levels (hypertriglyceridemia) •Uncontrolled diabetes •Hormonal disturbances •Polycystic Ovary Syndrome •Depression •Sleep apnoea •Skin tags and ancanthosis nigricans (brown to black, poorly defined, velvety hyper-pigmentation of the skin, usually found in body folds) •Blurred vision •Memory problems and general mental fogginess •Peripheral neuropathy (damage to the nerves of the peripheral nervous system). The peripheral nervous system transmits information from the brain and spinal cord (the central nervous system) to every other part of the body. It can range from just temporary numbness and tingling all the way through to organ failure depending on the extent of the neuropathy and which nerves are actually implicated As yet, the exact mechanisms of the pathways of Syndrome X are not fully understood. Certainly the pathophysiology of Syndrome X is very complex indeed. (Pathophysiology refers to the changes in body function brought about by the condition). How do I know if I have Syndrome X? The exact methods for diagnosing Syndrome X may vary but using the criteria as laid down by the US Third National Health and Nutrition Examination Survey (NHANESIII), and the National Institute of Health (NIH), a person has Syndrome X if they have three or more of the following conditions: •Waist circumference greater that 40 inches (102 cm) in men, greater that 35 inches (88 cm) in women •A serum triglyceride level above 150mg/L (1,7 mmol/L) •HDL cholesterol below 40 mg/dL (1.04 mmol/L) in men, below 50 mg/dL (1.29) in women •Blood pressure raised; above 135mg/85mm Hg, or taking a hypertensive medication •Fasting blood glucose above 110mg/dL (6.1 mmol/L) or taking antidiabetic medication What are the risk factors for developing Syndrome X? Syndrome X appears to have developed from our body’s inability to deal effectively with modern day life. Our ancestors were cave dwellers who lived a life that would be unrecognisable today - not only would their diet have been entirely different comprising of nutrient-rich, low carbohydrate foods but their levels of every day activity would have been much greater than that of most people today. But while the way in which we live has radically altered over the generations, our bodies are still genetically hardwired to thrive on the diet and lifestyle of our ancestors. In other words, our bodies haven’t yet evolved to match today’s world and this conflict between what our bodies need to be at their best and what they are actually getting appears to be the root cause of why conditions like Syndrome X have emerged. And even if scientists are not yet completely certain about the pathophysiology of Syndrome X, it’s clear that certain factors are at play. The most important risk factors are: •Being overweight •Being older •Having a sedentary lifestyle i.e. low physical activity combined with excess calorie intake •Having a degree of insulin resistance where the natural hormone insulin becomes less effective at lowering blood sugars. In order to try and compensate, the pancreas pumps out more and more insulin. Over time high levels of insulin build up in the blood stream. The resulting increase in blood glucose that occurs when someone is insulin resistant may raise blood sugar levels outside the normal range. This can have significant adverse health effects. In other words, most patients with Syndrome X are older, obese, insulin resistant and sedentary although there is some debate as to whether obesity and insulin resistance are actual underlying causes or whether they are in fact consequences of the condition. In many cases too, a number of blood markers are also elevated including C-Reactive Protein, Interleukin 6, Fibrinogen and Tumour Necrosis Factor-alpha. Obviously this means that there are some risk factors for developing Syndrome X that we simply cannot avoid and do nothing about - after all you cannot, for example, help the fact that you are getting older. And there can be no doubt that Syndrome X is an age related problem. It’s estimated that a staggering 44% of the U.S. population older than age 50 is affected by Syndrome X! This kind of correlation between age and prevalence is seen in most populations throughout the world, with women more likely to be affected than men. Certain diseases are also associated with an increased risk of developing Syndrome X. Not surprisingly, around 75% of people with either Type 2 diabetes or the pre-diabetic state of impaired glucose tolerance have Syndrome X. But Syndrome X is also linked with a variety of other illnesses. For example it appears that people with schizophrenia may have a predisposition to the condition. Over 30% of schizophrenics have Syndrome X with the prevalence being higher in women than men(3). Research is beginning to reveal similar associations between rheumatic diseases and Syndrome X(4). Genetics also play their role - for example some people are genetically predisposed to developing insulin resistance. Again there is little that you can do about your genetic make-up, although if you are aware of a genetic issue then you should perhaps strive to do your best to minimise other risk factors that you can influence in order to reduce your chances of developing the syndrome. And there are a number of risk factors that relate to Syndrome X that are indeed within our control to a greater or lesser extent and these are essentially matters that relate to the way in which we live our lives. Take the example of insulin resistance again. While some people are genetically predisposed to developing insulin resistance, others develop the condition through high stress and unhealthy lifestyles. Lifestyle factors and Syndrome X Lifestyle factors that relate specifically to Syndrome X include: 1. Being overweight/obese One of the key features of Syndrome X is central adiposity - that is to say being overweight / obese with the weight gain predominantly around the abdomen giving the classic apple shape. Of course, in many cases it’s easy to tell when someone suffers from central obesity just by looking at them, but the actual severity of their weight gain is determined by waist and hip measurements. A waist circumference of over 102 cm (40 in) in men and greater than 88 cm (35 in) in women, with a waist-hip ratio of greater than 0.9 for men and more than 0.85 for women are all clear indicators of central obesity problems. Whilst the immediate cause of weight gain is a basic imbalance between the amount of calories consumed and the amount of calories used i.e. you’ll put on weight if you consume more calories than you use, the fundamental cause of obesity is not well understood. It is likely to be a combination of environmental and genetic factors. Scientists are still not clear either as to what specifically causes a central distribution of fat although you cannot avoid the fact that it is heavily correlated with a sedentary lifestyle and overeating. Prolonged elevated cortisol levels (hypercortisolism) (which we discuss further below) can occur if you are stressed or if you suffer from diseases such as Cushing’s syndrome, and are known to result in increased central adiposity. Even some prescription medications can cause weight problems. Although the prevalence of Syndrome X is in the large part determined by the strong associations between the condition and our increasingly overweight populations, you shouldn’t lose sight of the fact that you may be of normal weight but still have Syndrome X if other symptoms exist. 2. Stress We all know that being stressed for prolonged periods of time is bad for our health. This is particularly so because stress causes our cortisol levels to become elevated which is definitely not a good thing. When we are stressed over long periods of time the hormonal balance of the hypothalamic-pituitary-adrenal axis (or HPA axis) is interfered with. If this happens, cortisol levels increase which in turn raises glucose and insulin levels. Ultimately this rise in cortisol levels can result in increased central obesity (weight gain around the centre of the body – ‘apple shaped’ weight gain), insulin resistance, dyslipidemia ( an abnormal amount of lipids such as cholesterol and /or fat in the blood) and increased blood pressure (hypertension). None of these things are good for our health and increase our risk of developing serious conditions such as Type 2 diabetes and cardiovascular disease. 3. Sedentary lifestyle Many of the components of Syndrome X are inextricably linked with leading a sedentary lifestyle. If you are physically inactive then you are more likely to be overweight / obese (particularly around the abdomen as in central adiposity (see above), have higher HDL cholesterol (often called the “bad” cholesterol), and, particularly if you are genetically susceptible, have increased blood pressure and elevated triglyceride and glucose levels. Such lifestyles can trigger insulin resistance, full blown Type 2 diabetes and, of course, also increase your risk of developing cardiovascular disease. Insulin resistance and its effects on weight Whether or not you are unfortunate enough to have inherited specific genes that pre-dispose you to developing insulin resistance (one of the key indicators of Syndrome X) is a matter of genetics. However, experts agree that excess weight and lack of exercise can have a huge impact whether you are genetically pre-disposed or not. And there can be no doubt that insulin resistance also has a clear impact on weight gain. The role of insulin is to allow glucose (a simple sugar) to travel from the bloodstream into your cells. Glucose is vital for life - it is the energy source used for every metabolic process. When we eat foods high in refined carbohydrates, our digestive systems convert the starches and complex sugars that these carbohydrates provide us with, into glucose which is absorbed into our blood streams. Insulin levels surge in response to the increased glucose levels in order to remove the sugar from the blood and move it in to your cells. Generally this system works very well. But if insulin spikes too often from a diet rich in the high-carbohydrate foods that trigger insulin secretion, your cells respond by decreasing their reactivity and number of insulin receptors on their surfaces. This is insulin resistance. Eventually insulin resistance prevents glucose from being transferred into your cells, which leads to high blood sugar levels and deprives your cells of the energy that they need to function. Instead, the glucose produced goes into the long-term energy storage system where it is converted into fat. This all means that when you become insulin resistant, even though there may be plenty of glucose available in your blood stream, your cells are literally starving for energy. To make matters worse, high insulin levels cause your hypothalamus (your master gland) to send you hunger pangs! This manifests itself in cravings for carbohydrate laden foods. You become fatigued and weight gain is inevitable. If steps are not taken insulin resistance will eventually turn into full blown Type 2 diabetes. Insulin resistance and aging Insulin resistance doesn’t just make you put on that hard to shift weight around your middle, it also makes you age prematurely. The problem is that if your glucose levels remain elevated then your body is at risk of suffering damage from glycation. Glycation is the reaction that occurs when simple sugar molecules such as glucose become attached (bind) to proteins (or lipid fats) without the controlling action of an enzyme. This process, also called non-enzymatic glycosylation, results in the formation of rogue molecules known as advanced glycation end products (AGEs). These AGEs interact with adjacent proteins (cross link) which results in impaired function, serious damage to cell membranes and collagen fibres, free radical formation and accelerated aging. AGEs are, therefore, linked to many age-related diseases and conditions. For example, they can lead to the stiffening of connective tissue which manifests itself as sore, stiff joints and joint pain, the development of senile cataracts and the breakdown of cellular communications and repair processes. Eventually, body tissues become diseased as they are irreversibly transformed by the destructive actions caused by AGEs. Unfortunately AGE production increases naturally in all of us as we grow older, but if you suffer from insulin resistance as present in Syndrome X the situation in is exacerbated. With high glucose levels available to fuel the destructive process, your body will produce even more AGEs and you will be susceptible to even greater levels of AGE damage which will ultimately result in premature aging. Losing weight and Syndrome X By now you are probably thinking that you are doomed and that other than changing some lifestyle factors there maybe little that you can do to avoid developing Syndrome X or that you may already have the condition. Certainly lifestyle changes can help and as we have seen, losing weight maybe of significant benefit. But what if you have tried to lose weight and simply don’t seem to be able to? Or you have lost weight only to put it all back on and more after you’ve come off your diet? Or you have spent years being a yo-yo dieter? Syndrome X could be sabotaging any attempt that you may make to try and shed those extra pounds. In fact, if you have Syndrome X then you are probably caught in a vicious weight gain cycle. There are two main reasons why someone with Syndrome X cannot lose weight: •Your already elevated insulin levels make you feel hungry and you crave carbohydrates in particular. You’ll want to eat all those things that are not good for you like sweets, chips and sweet sugary drinks. The problem is that if you consume a lot of carbohydrates your insulin levels will simply go higher which in turn will make you even hungrier. And if that wasn’t bad enough, insulin preferentially converts sugar into fat storage deposits, instead of muscle and liver glycogen stores - in other words insulin encourages your body to lay down fat deposits •Your liver is not working properly and instead of burning fat and pumping excess fat out of the body through bile, the reverse is happening and your liver is storing fat. This means that you just keep getting fatter especially around the abdominal area which is as we have seen is not good news How Diet Pro can help As we’ve established, Syndrome X is a huge problem that affects millions of people around the globe. It increases your risk of developing potentially catastrophic medical conditions and is in all likelihood wrecking any attempts that you may make to try and lessen your risks by preventing you from losing weight. And as we have already seen above, when it comes to diet, carbohydrates are the real enemy if you suffer from Syndrome X. Therefore, following a low carbohydrate diet is the way forward as it can help to reduce your blood sugar and insulin levels. By simply taking a convenient single capsule dose of Diet Pro before each meal you can achieve many of the benefits that come from a low carbohydrate diet. The new and unique formula contained in Diet Pro has been specifically designed to help prevent and reverse the negative effects of dietary carbohydrates. By helping to slow carbohydrate absorption, Diet Pro helps to improve the body’s insulin regulation which is immensely beneficial to your health. For example, by bringing your insulin regulation under control you diminish your risks of developing full blown Type 2 diabetes. But bringing your blood sugars and insulin levels under control is also crucially important if you want to successfully lose weight on a long term basis. If you don’t do this your likelihood of shedding those extra pounds permanently is highly unlikely. So just what’s in Diet Pro? Diet Pro contains a unique blend of natural extracts that are contained in a specific formulation that has been designed to slow carbohydrate absorption and thereby improve insulin regulation and energy production. And as we have seen, regaining control of your insulin levels is crucial if you are to try and avoid the devastating impact of Syndrome X. It also has a powerful effect upon weight loss. Your body no longer craves carbohydrate rich food which enables you to stick to your diet more easily and achieve results faster. In other words, Diet Pro can help you achieve the ultimate goal of long term, significant weight loss. To achieve these benefits, the key components of Diet Pro are outlined below: 1. Chromium (in the form of picolinate) Chromium is an essential nutrient involved in both normal carbohydrate and lipid metabolism. Its benefits include helping to lower blood glucose levels and reducing insulin resistance. It’s also thought to be involved in the building of new muscle and acts as a fat burner. It is therefore a key supplement when it comes to fighting Syndrome X. Most experts agree that chromium in the form of chromium picolinate offers the most effective way of transporting chromium into your cells. 2. Oolong tea extract The health benefits of taking various tea extracts have long be known about. Oolong tea (whose name comes from the Chinese for “black dragon”) is the same leaves that are used to make green tea. Both green tea and oolong tea contain catechins, powerful antioxidant compounds which aid in fighting disease and aging. Oolong has been attributed with many health benefits including boosting metabolism and immune system (it has both antiviral and antibacterial properties), promoting weight loss, aiding in the relief from allergies, helping to ease eczema and being beneficial to those suffering from diabetes. Oolong tea is also known to be especially effective in reducing the levels of LDL “bad” cholesterol. 3. Green tea extract Green tea is also processed from the leaves of the camellia sinensis plant but has not been fermented for as long as oolong tea. The health benefits of green tea have been known about for a long time and it has been widely used throughout China and India for centuries. One of the key benefits of green tea is that it is rich in antioxidants which are vital if you are to prevent damage from free radicals. The potent antioxidant properties of green tea are derived from the fact that it contains both polyphenols and epigallocatechin gallate. In fact green tea’s antioxidant activity is more than 100 times more powerful than that of Vitamin C or E. But green tea is not just a superior antioxidant. Researchers are now looking at its potential in the fight against cancer and its ability to improve cardiovascular health particularly as it appears to be able to reduce LDL ”bad” cholesterol levels and improve the oxidation of fat. It may also be useful in the battle against obesity because it appears to be able to help suppress appetite. 4. Banaba Extract Using banaba extract is nothing new - for centuries it has been used throughout South East Asia to treat a number of conditions including obesity and diabtetes. The reason for its success as a treatment of these conditions lies in the fact that the leaves of the banaba plant contain corosolic acid - a plant insulin, with insulin like effects. Corosolic acid works by activating the transport of glucose across cell membranes which, in turn, significantly reduces blood sugar levels. 4. Gymnema Sylvestre Extract Gymnema sylvestre, a herb that is native to the tropical forests of southern and central India, has been used for around two centuries as a naturopathic treatment for diabetes. The active ingredient in gymnema sylvestre is gymnemic acid which is extracted from the plant’s roots and leaves. It aids diabetes by helping to lower and balance blood sugar levels. Gymnemic acid is effective in this role because of the unique shape of its molecules which are similar to glucose molecules. This allows gymnemic acid molecules to fill cell receptors in the lining of the intestines, thereby preventing the uptake of sugar molecules. By helping to reduce cravings for sweets and by helping to make carbohydrates available for burning rather than being turned into fat stores, gymnema sylvestre is also a useful addition to any weight loss plan. Claims have also been made that it lowers triglyceride and HDL “bad” cholesterol levels but further research in this area is still needed. 6. Cinnamon Extract Scientists from the US Department of Agriculture along with those from several universities have identified cinnamon as being an effective treatment for high blood sugar. They have been able to isolate compounds in cinnamon bark that have been proven to lower blood sugar levels significantly(5,6). Cinnamon extract is also highly beneficial when it comes to improving glucose and fat metabolism. Studies have shown that cinnamon can lower blood glucose by 18% - 29%. It can also cause triglycerides, total cholesterol, and LDL (bad) cholesterol levels to fall by between 7% and 30%. Therefore, cinnamon extract can play a crucial role when it comes to fighting Syndrome X. Bitter Melon Extract Bitter melon (momordica charantia) has long been known for its medicinal benefits. It’s a common fruit that grows throughout much of the Tropics and in South America it is specifically cultivated as both a food and a medicine. Its health benefits include acting as an antiviral medication, as treatment for colic and, importantly in this context, acting as an agent to lower blood sugars. Numerous studies have examined the benefits and actions of bitter melon. These studies have revealed that its blood sugar lowering capabilities come from its ability to promote insulin release, enhance cellular uptake of glucose and to intensify the effectiveness of insulin. It is also known to have significant effects on reducing both total cholesterol and triglycerides. 8. Coccinia Indica Extract Coccinia indica (also known by the scientific names C. cordifolia and C. grandis and the common names kundru, dondakaya, kovakkai and tindora, among many others) is a gourd plant native to India, where it is used as a vegetable. Extracts of the plant have been used for centuries in Ayurvedic medicine (a system of traditional medicine from the Indian subcontinent). In more recent times it has been the subject of scientific research into its positive effects on lowering blood sugars. For example in a study published in the February 2008 edition of the journal Diabetes Care(7), researchers from the Institute of Population Health and Clinical Research in Bangalore conducted a randomized, double-blind study on 60 patients with mild Type 2 diabetes. Half of the study participants received 1g of coccinia indica extract a day, the other half received a placebo. After 90 days, the participants who had received the extract showed marked decreases in their blood glucose levels - fasting blood glucose levels were reduced by 16 % and post-prandial (after meal) blood glucose levels by 18%. 9. Salacia Reticulata The salacia reticulata plant grows wild in Sri Lankan and Indian forests. It is known to have powerful starch blocking activity which makes it a significant weapon against Syndrome X and the fight against excess weight. For example, in one study carried out at the Kyoto Pharmaceutical University, researchers were able to demonstrate that daily consumption of a hot water extract of Salacia reticulata suppressed body weight by as much as 14%! (8) 10. Vanadium (vanadyl sulphate) Along with chromium picolinate, vanadium is perhaps the most important supplement that you can take when it comes to fighting Syndrome X. Vanadium is a trace element known to be highly effective at lowering blood glucose levels and stabilizing insulin levels. In fact, vanadium is sometimes referred to as the “insulin Mineral”. It is also known to help lower blood pressure and serum cholesterol levels as well as reduce the severity of the effects of Syndrome X. For example, researchers from the University of Texas Health Science Center concluded that vanadyl sulfate (the sulfate salt of vanadium) administered at maximal doses for 6 weeks improved both liver and muscle insulin sensitivity in patients with Type 2 diabetes(9). Conclusion For those suffering from Syndrome X, Diet Pro offers a convenient, simple yet effective way of tackling the issue of carbohydrate consumption and the devastating effects that too many carbohydrates can have on your body. With its amazing combination of active ingredients, Diet Pro not only helps you to maintain healthy blood glucose levels and negate the effects of a carbohydrate rich diet, it also offers you the support that you need to stick to your diet more easily and finally get rid of that weight that you just haven’ t been able to shift. How to take Diet Pro? Taking Diet Pro couldn’t be easier. Just take 1-2 capsules with each meal (up to a maximum of 6 per day) DietPro - Aiding long term, significant weight loss Scientists from the US Department of Agriculture and several Universities have confirmed that extracts of cinnamon lowers blood sugar levels significantly, a key factor in Syndrome X, which is the secret to the puzzle of real, long term and significant weight loss. So we have added those same extracts of cinnamon and a unique blend of specialized tea extracts to maximize the starch blocking, insulin balancing and energy production effects of Diet Pro. Furthermore, there are nutraceuticals in Diet Pro’s formula- proven to support healthy glucose and lipid levels, improve glucose oxidation and protect the pancreas. All factors leading toward weight loss and helping you to stick to your diet more easily, getting better results faster. Low carbohydrate diets work (in part) by reducing your blood sugar and insulin levels. This is a good thing because the combination of elevated blood sugar and insulin triggers your body to start storing fat. Plus, the excess blood sugar and insulin cause all sorts of long term health problems such as increasing the rate of aging and the risk of heart disease. Now, with Diet Pro, you can get many of the benefits of a low carbohydrate diet by taking a convenient single capsule before each meal. What our customers say... I’ve been on numerous diets, but now taking Diet Pro before each meal I am finding it easier to stick to my diet and the results look good, I’m sure I am losing weight quicker and keeping my weight off. Even my husband has noticed!. J.K., Vermon
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