Product Information

Creatine is an Amino Acid. Creatine Monohydrate is an excellent supplemental form of Creatine and facilitates Muscle Growth is useful for the Cardiovascular System, (AIDS), Fibromyalgia, Muscular Dystrophy and Rheumatoid Arthritis. It possesses Anti-oxidant properties.

Description

Creatine Monohydrate is a modified form of Creatine that is widely used as an effective supplemental form of Creatine. Physically it is a white, gritty, odorless, tasteless powder.Health Benefits of Creatine MonohydrateCardiovascular SystemCreatine Monohydrate may be of benefit to Congestive Heart Failure (CHF) patients as CHF patients often exhibit endogenous intracellular Creatine levels approximately 20% lower than normal and supplementary Creatine Monohydrate (20 grams per day) may help to restore normal Creatine levels.

Cells

Creatine Monohydrate supplementation may help to restore low Creatine Phosphate levels to normal in people with impaired function of the Mitochondria of Cells (known medically as Mitochondrial Cytopathy).

Eyes/Vision

Creatine Monohydrate (1,500 - 3,000 mg per day) may halt the further progression of Gyrate Atrophy of the Choroid and Retina.

Immune System

Creatine Monohydrate ((10,000 - 15,000 mg per day) may counteract the Cachexia associated with Acquired Immune Deficiency Syndrome (AIDS) - Creatine Monohydrate may increase Muscle mass and Muscle Strength in AIDS patients.

Metabolism

Creatine Monohydrate possesses Antioxidant properties:

- Creatine Monohydrate may scavenge Peroxynitrite Free Radicals.
- Creatine Monohydrate may scavenge Superoxide Free Radicals.

Creatine Monohydrate may improve Athletic Performance , may delay the onset of Fatigue during intensive Exercise and may accelerate recovery time after intensive Exercise.

- Creatine Monohydrate may decrease the production of Ammonia during Exercise.
- Creatine Monohydrate (6,000 mg per day) may inrease the “interval power” of people who undertake Endurance Exercise (in the relevant study, “interval power” was defined as the ability of tri-athletes to run up steep hills).
- Creatine Monohydrate may improve the performance and Stamina of people who undertake Isotonic Exercise (weight lifting).

- Creatine Monohydrate may inhibit the endogenous production of Lactic Acid within the Muscles during Exercise by up to 41%.
- Creatine Monohydrate may alleviate Fatigue in people with impaired Mitochondrial function.

Creatine Monohydrate may increase the body’s Basal Metabolic Rate (BMR).
Creatine Monohydrate may help to counteract Cachexia.
Creatine Monohydrate may lower total serum Cholesterol levels (by up to 15%).

Creatine Monohydrate may increase nitrogen retention in the body.

Creatine Monohydrate may delay the onset of (muscular) Fatigue in people who undertake intensive Exercise and may also alleviate Fatigue in people with impaired Mitochondrial function. Creatine Monohydrate may also alleviate mental Fatigue.
Creatine Monohydrate may improve Stamina (especially in persons who Exercise) - it permits Muscles to perform harder for longer periods of time.
Creatine Monohydrate may lower elevated serum Triglycerides levels.

Musculoskeletal System

Fibromyalgia patients often have significantly lower levels of Creatine than healthy people (and supplemental Creatine Monohydrate may help to restore endogenous Creatine levels to normal in Fibromyalgia patients) - studies to determine whether supplemental Creatine Monohydrate could alleviate Fibromyalgia have not yet been performed.
Creatine Monohydrate may alleviate Muscle Cramps.

Creatine Monohydrate may stimulate Muscle Growth and may increase Muscle Strength when used in conjunction with a properly designed training program:

- Creatine Monohydrate has more affinity with Type IIB Muscle Fibers than with other types of Muscle Fibers.
- Creatine Monohydrate, by increasing endogenous Creatine Phosphate levels, facilitates the endogenous synthesis of Muscle Proteins (e.g. Actomyosin) by Ribosomes.
- Clinical studies have proven beyond any doubt that supplemental Creatine Monohydrate increases one-repetition maximum lifting strength in bodybuilders (i.e. in people who undertake Isotonic Exercise).

- Creatine Monohydrate may facilitate the differentiation of Satellite Cells.

The Creatine component of Creatine Monohydrate concentrates in the Muscles.
Creatine Monohydrate may increase Muscle Strength and may increase Muscle mass in Neuromuscular Disease patients:

- Creatine Monohydrate may increase Muscle Strength and may increase Muscle mass in Muscular Atrophy patients.
- Creatine Monohydrate may increase Muscle Strength and may increase Muscle mass in Muscular Dystrophy patients.
- Creatine Monohydrate (5,000 mg per day) (when combined with Isotonic Exercise) may increase Muscle Strength in Myasthenia Gravis patients.
- Creatine Monohydrate is speculated to alleviate Parkinson’s Disease and it is presently undergoing investigation for the treatment of this condition.

Creatine Monohydrate (5,000 mg per day combined with Isotonic Exercise) may help to prevent Osteoporosis by increasing Bone Mineral content.
Rheumatoid Arthritis patients often have significantly lower levels of Creatine than healthy people (and supplemental Creatine Monohydrate may help to restore endogenous Creatine levels to normal in Rheumatoid Arthritis patients) - studies to determine whether supplemental Creatine Monohydrate could alleviate Rheumatoid Arthritis have not yet been performed.

Nervous System

Creatine Monohydrate is speculated to alleviate Alzheimer’s Disease and it is presently undergoing investigation for the treatment of this condition.
Creatine Monohydrate is speculated to alleviate Amyotrophic Lateral Sclerosis (ALS) and it is presently undergoing investigation for the treatment of this condition.

Creatine Monohydrate may help to protect the Brain from Concussion and may accelerate the healing of the Brain after Concussion. It may be particularly useful if it is supplemented prior to the occurrence of the Brain injury that causes Concussion.
Creatine Monohydrate may be a useful therapy for Huntington’s Disease.

Creatine Monohydrate may increase Intelligence.
Creatine Monohydrate may alleviate a subset of cases of Mental Retardation (when Mental Retardation is caused by depletion of Creatine in the Brain).
Creatine Monohydrate may help to prevent/treat Parkinson’s Disease.

Creatine Monohydrate may improve Short-Term Memory.
Creatine Monohydrate (10,000 mg per day) may alleviate the symptoms of Spinocerebellar Ataxia Type 7.

Creatine Monohydrate may minimize the Brain damage the occurs following a Stroke.

Creatine Monohydrate may Enhance the Function of these Substances

Amino Acids

Creatine Monohydrate increases plasma Creatine levels:

- Creatine Monohydrate may be the most efficient means of increasing endogenous Creatine Phosphate levels within the Muscles (via Creatine).

Krebs Cycle Chemicals

Creatine Monohydrate may increase the body’s production of Adenosine Triphosphate (ATP).

Nitrogen Products

Creatine Monohydrate (20 grams per day) may decrease the accumulation of Ammonia in the Blood Plasma during and after intensive Exercise.
Creatine Monohydrate may increase the oral bioavailability of exogenous Urea.

Proteins

Creatine Monohydrate may increase the endogenous synthesis of Actomyosin (including its two constituents - Actin and Myosin).

Creatine Monohydrate may Inhibit these Potentially Toxic Substances

Amino Acid By-Products

Creatine Monohydrate may decrease the body’s production of Ammonia during Exercise.

Amino Acids

Creatine Monohydrate is hypothesized to lower elevated Homocysteine levels (by “sparing” methyl groups normally used for the production of endogenous Creatine, permitting these methyl groups to be utilized for the proper metabolism of Homocysteine).

Neurotoxins

Creatine Monohydrate may counteract the toxicity of MPTP.

Organic Acids

Creatine Monohydrate may inhibit the endogenous production of Lactic Acid within the Muscles during Exercise by up to 41%.


These Substances may Enhance the Function of Creatine Monohydrate

Carbohydrates

Simple Sugars (e.g. Glucose) may increase the uptake of supplemental Creatine (and Creatine from Creatine Monohydrate) into Muscles (when Simple Sugars are consumed at the same time as supplemental Creatine or Creatine Monohydrate, Muscle Creatine concentration may increase far greater than when Creatine or Creatine Monohydrate supplements are consumed alone (without concurrent Simple Sugars)).

Hormones

Insulin may facilitate the transport of Creatine (from Creatine Monohydrate) into Muscle Fibers (Muscle Cells).

Proteins

Creatine Transporter Protein stimulates the transport of Creatine (from Creatine Monohydrate) into Muscle Fibers (Muscle Cells).

Proteins

Pinitol may increase the body’s retention of Creatine from Creatine Monohydrate.

These Substances may Interfere with Creatine Monohydrate

Alkaloids

Caffeine may reduce the effectiveness of supplemental Creatine.

Potentially Toxic Effects of Creatine Monohydrate

Excretory System

Long-term, excessive dosages of Creatine Monohydrate may cause Kidney damage (by over-burdening the workload on the Kidneys) - this warning does not apply to non-excessive doses of Creatine Monohydrate.

Bioavailability

Orally-ingested Creatine Monohydrate is efficiently absorbed intact via the Intestines into the blood stream:

- More than 95% of orally-administered Creatine Monohydrate is absorbed by the body.

Dosage Recommendations

Until 1997, it was generally believed that Creatine Monohydrate supplementation was not effective unless a “kick-start” dosage of 20 - 30 grams per day was used prior to a daily maintenance dosage of up to 15 grams per day. During 1996, Dr Paul Greenhaff (widely recognized as the world’s most knowledgeable Creatine researcher) showed that Creatine Monohydrate supplementation is equally effective when used at a continuous daily dosage of 3 - 5 grams per day.

Performance Enhancement

The recommended dosage of Creatine Monohydrate for people seeking to improve Athletic Performance, Muscle Growth and Muscle Strength is 3,000 - 5,000 mg (3 - 5 grams) per day:

- For people seeking Muscle Growth, the optimal strategy for the timing and dosing of Creatine Monohydrate supplements is 750 -1,250 mg taken 30 - 60 minutes prior to a workout, followed by a further 750 - 1,250 mg immediately after a workout. Two further doses of 750 -1,250 mg each should be taken at other times during the day.

Therapeutic Dosage - Cardiovascular System

The recommended dosage of Creatine Monohydrate for Congestive Heart Failure patients is up to 20,000 mg (20 grams) per day.

Toxic Dosage

Creatine Monohydrate is virtually non-toxic. The LD 50 (in mice) is in excess of 9,000 mg (9 grams) per kg of body weight

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