ARTHACTIN™

Arthactin™ is a natural traditional botanical formula to support healthy, flexible joints and contains botanical ingredients that have been used traditionally for inflammatory conditions.

Ingredients: Boswellia serrata, Commiphora mukul, Ginger, Curcuma longa, Fenugreek, Boerhaavia diffusa, and Piper Longum.

Indications: Supports Joint Health.

Packaging/Size: 90 Tablets

Osteoarthritis (OA), or is one of the oldest and most common types of joint conditions. It is characterized by the breakdown of the joint’s cartilage. Cartilage is the part of the joint that cushions the ends of bones. Cartilage breakdown causes bones to rub against each other, causing pain and loss of movement. Most commonly affecting middle-aged and older people, OA can range from very mild to very severe. It affects hands and weight-bearing joints such as knees, hips, feet and the back. The other common form of arthritis is Rheumatoid arthritis (RA). RA involves inflammation of the lining of many different joints in the body. In some people, RA can also affect other parts of the body, including the blood, the lungs, and the heart. Inflammation of the joint lining, called the synovium, can cause pain, stiffness, swelling, warmth, and redness. The affected joint may also lose its shape, resulting in loss of normal movement. RA can last a long time, and can be a condition of flares (active) and remissions (little to no activity. Arthritis is caused by an immune system disorder commonly referred to as autoimmune disorder. It is characterized by chronic inflammation of joints, immobility of joints, chronic pain and water retention. Conventional therapies used in the treatment of arthritis are usually palliative and offer no long term solution. Ayurveda recognizes the root cause of Arthritis and has been successfully used in the treatment of various forms of arthritis for centuries.

Boswellia serrata. The therapeutic value of its gum (sallaki) has been known. It posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract (BSE) in 30 patients of osteoarthritis of the knee, 15 each receiving active herb or placebo for eight weeks. After the first intervention, washout was given and then the groups were crossed over to receive the opposite intervention for eight weeks. All patients receiving herb treatment reported decrease in knee pain, increased knee flexion and increased walking distance. The frequency of swelling in the knee joint was decreased.

Commiphora mukul or Guggul is an oleoresin of the herb Commiphora mukul (CM). A study was conducted using an outcome, quasi-experimental, model. Thirty male and female participants meeting the

inclusion/exclusion criteria, with a score of 2 or more on the Kellegran-Lawrence scale for at least 1 knee, were admitted in the study. CM was administered in capsule form (500 mg concentrated exact delivered TID) along with food. The WOMAC Total Score was used as a primary outcome measure. VAS scales, 6-minute walk-test, and WOMAC subscales were used as outcome measures. RESULTS: At the end of treatment, there was a significant difference in the scores of the primary and secondary outcome measures.

Ginger has been used traditionally as an anti-inflammatory and for healthy joints.

Curcuma longa contains Curcumin which is the active anti-inflammatory agent found in the spice turmeric (Curcuma longa). It has been shown to inhibit the activity of the 5-lipoxygenase and cyclooxygenase enzymes, blocking the synthesis of pro-inflammatory eicosanoids (PG-2, LTB-4). A large double-blind study demonstrated that curcumin was as effective as a powerful anti-inflammatory herb, phenylbutazone in reducing pain, swelling and stiffness in rheumatoid arthritis patients.

Piper longum is a traditional herb used historically for lung and inflammatory conditions.

References:

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• Ammon HP, Wien Med Wochenschr. 2002;152(15-16):373-8.

• Sandar O, Herbon G, Rau R; Z Rheumatol. 1998 Feb;57(1):11-6. German

• Safayhhi M, Mack T, Sabieraj J, Anazodo NI, Subramanian LR, Ammon HP; J Pharmacol Exp Ther. 1992 Jun; 261(3): 1143-6

• Arora R B et al. Anti-inflammatory studies on curcuma longa (turmeric). Ind J Med, Res 1971; 50: 1289-95.

• Indian Journal of Experimental Biology 32(9): 633-636. {a} Dep. Pharmacol., S.M.S. Med. Coll., Jaipur, India

• Dahanukar, S. A., S. M. Karandikar, et al. (1984). Efficacy of Piper longum in childhood asthma. Indian Drugs 21(9): 384-388