Product Information

In a sublingual form, (A superior form of Vitamin B12 for neurological benefits) Many researchers indicate that this form is worth "searching for" as clinical trials have shown that in supplement form, it is far superior to other forms of Vitamin B12 supplements in terms of its ability to enhance human health. Useful for Ears/Hearing, (AIDS), Systemic Lupus Erythematosus (SLE), Chronic Fatigue Syndrome (CFS). Vitamin B12 inhibits the replication of the HIV. Helps to prevent Breast Cancer, Cardiovascular Diseases and Heart Attacks. Assists with Mood, Multiple Sclerosis, Fatigue, Energy, Fibromyalgia, Insomnia, Intelligence and Learning. Improves quality of Sleep by increasing endogenous Melatonin levels. Tobacco smokers are often found to be deficient in Vitamin B12. Alleviates Asthma, Female and Male Infertility, Male Impotence.

Description

This topic outlines the various forms of supplemental and pharmaceutical Vitamin B12.

Forms of Vitamin B12

Adenosylcobalamin (also known as ado-Cbl; Cobamamide; Coenzyme B12; Deoxyadenosylcobalamin; Dibencozide; Dimethyl Benzimidazole-cobamide Coenzyme) is an active endogenous coenzyme form of Vitamin B12 that helps to maintain the correct Fatty Acids in Myelin, the fatty sheath surrounding Nerves. Adenosylcobalamin is formed endogenously and its impaired biosynthesis can lead to a condition known as Methylmalonic Academia. Approximately 70% of the Liver’s Vitamin B12 reserves are in the form of Adenosylcobalamin. Although some manufacturers produce this form of Vitamin B12 in supplemental form, it is more expensive than Cyanocobalamin. Most supplemental Cyanocobalamin is converted within the Intestines to Adenosylcobalamin.

Cobalamin (Cbl) is a general term for all Vitamin B12-like compounds (i.e. compounds that contain the Dimethylbenzimidazolylcobamide nucleus that characterizes Vitamin B12).
Cyanocobalamin (also known as Cytamen) is a complex of Cyanide and Cobalamin. This form of Vitamin B12 is the form most commonly found in Vitamin B12 supplements. It must be converted to either of the active Coenzyme forms within the body in order to exert therapeutic effects. It is not as effective as the Adenosylcobalamin, Methylcobalamin or Hydroxocobalamin forms of supplemental Vitamin B12 but is more stable than the Hydroxocobalamin form. The Liver converts approximately 1% of Cyanocobalamin to the Methylcobalamin form of Vitamin B12. Most supplemental Cyanocobalamin is converted within the Intestines to Adenosylcobalamin.

Hydroxocobalamin (also known as Hydroxocobemine; Hydroxycobalamin; Vitamin B12b) is the ideal form of supplemental Vitamin B12 (due to it remaining in circulation for longer than other forms of Vitamin B12). This form is only administered via intramuscular (IM) injection. Hydroxocobalamin differs from Cyanocobalamin by the presence of a Hydroxyl Ion in place of the Cyanide Ion.
Mecobalamin is a form of Vitamin B12 that is suitable for intravenous injection (by a physician).

Methylcobalamin (also known as met-Cbl; MeCbl; Methyl-B12) is an active endogenous Coenzyme form of Vitamin B12 that transfers a Methyl group from an inactive form of Folic Acid to Homocysteine forming Methionine. This is the only active endogenous coenzyme form of Vitamin B12 that is available as a supplement (in tablet form). Methylcobalamin accounts for approximately 70% of the total Blood Plasma Vitamin B12 reserves. Clinical trials have shown that supplemental Methylcobalamin is greatly superior to other forms of Vitamin B12 supplements in terms of its ability to enhance human health. The Liver converts approximately 1% of the Cyanocobalamin form of Vitamin B12 to Methylcobalamin.