Product Information

Natural anti-inflammatory and healing support for joints. Contains Glucosamine Sulphate and Phytosterols. Glucosamine Sulphate benefits the joints by alleviating pain, reducing inflammation, healing damaged tissue and improving motion by joint lubrication.  Phytosterols (derived from plants) help prevent inflammation and reduce pain.

Description

This product does NOT contain Chondroitin Sulphate.

Why this product does NOT contain Chondroitin Sulphate?

The Chondroitin molecule is much larger molecule: (Chondroitin Sulphate is 250 times larger than Glucosamine Sulphate), and has an absorption rate of 13% according to some studies (compared to the 98% absorption of Glucosamine Sulphate). Added to this is the fact that Chondroitin Sulphate is derived from Shark or Bovine cartilage.

Secondly, since there is no evidence that Chondroitin enhances the benefits of Glucosamine, and, given that they work in the same way, and, given that Chondroitin is more expensive, one may want to consider a product without Chondroitin. The hypothesis that Glucosamine Sulphate and Chondroitin Sulphate work synergistically in the support of osteoarthritis remains unproven. The fact that they are structurally similar suggests that they may act in similar ways.

Myths Dispelled

Supplemental oral Chondroitin Sulfate is NOT an effective therapy for the treatment of Osteoarthritis (due to the Chondroitin Sulfate molecule being too large to penetrate Joint Cartilage for delivery to Chondrocytes to enhance endogenous Glycosaminoglycans (GAGs).

Supplemental Glucosamine Hydrochloride or supplemental N-Acetyl-Glucosamine (NAG) are NOT effective therapies for the treatment of Osteoarthritis (primarily because they do not contain Sulfur within their molecular structures).

Why Glucosamine SO4 (Sulphate)?

There are 2 forms of Glucosamine, i.e.: Glucosamine Sulphate (SO4) and Glucosamine Hydrochloride (HCl). Glucosamine SO4 is a better source as it provides sulphur, a very important nutrient for joints (that is the reason MSM is also used for joints... MSM is just a sulphur source). All of the positive clinical studies performed on Glucosamine employed supplements containing Glucosamine Sulphate, not Glucosamine HCl.

What does it do?

Glucosamine (improves lubrication, pain killer, anti-inflammatory-through it’s non steroid mechanism, promotes healing). Glucosamine Sulphate provides the joints with the building blocks they need to repair damage caused by osteoarthritis or injuries. Specifically, Glucosamine Sulphate provides the raw material needed to manufacture a mucopolysaccharide (called glycosaminoglycan) found in cartilage. Glucosamine Sulphate may also play a role in wound healing.

Benefits and uses

The most promising use for Glucosamine is in the treatment of osteoarthritis, the most common form of arthritis. Unlike non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, etc.), which degrade cartilage, Glucosamine may not only relieve symptoms of joint pain and tenderness but actually stop or reverse the degenerative process. Although definitive long-term studies have yet to be done, some twenty clinical trials have showed that one form, Glucosamine Sulphate, can gradually reduce pain while improving range of motion and walking speed in people with osteoarthritis. In addition to possibly alleviating symptoms of osteoarthritis, Glucosamine Sulphate may also benefit wounds and kidney stones.

Glucosamine Sulphate is absorbed quickly and easily. Lab tests show it is 98% absorbable -- and because the molecules are small and simple, they actually penetrate the cartilage, where they can help build the special proteins that keep cartilage strong and healthy.

There is promising evidence that Glucosamine can both control pain and slow down or reverse the progression of degenerative joint disease. Recent studies suggest that Glucosamine may work by mechanisms other than synthesizing new cartilage. In particular one study suggest that anecdotal reports of rapid symptomatic response to high-dose Glucosamine in osteoarthritis are not credibly explained by the traditional view that Glucosamine promotes synthesis of cartilage proteoglycans. An alternative or additional possibility is that Glucosamine stimulates synovial production of hyaluronic acid (HA), which is primarily responsible for the lubricating and shock-absorbing properties of synovial fluid. Many clinical and veterinary studies have shown that intra-articular injections of high-molecular-weight HA produce rapid pain relief and improved mobility in osteoarthritis. HA has anti-inflammatory and analgesic properties, and promotes anabolic behaviour in chondrocytes. The concentration and molecular weight of synovial fluid HA are decreased in osteoarthritis; by reversing this abnormality, high-dose Glucosamine may provide rapid symptomatic benefit, and in the longer term aid the repair of damaged cartilage.

Why Phytosterols?

Phytosterols (anti-inflammatory-through it’s steroidal mechanism i.e. decreases cortisol & increases DHEA levels, immune system modulator i.e. fights infections especially those caused, post exercise, from high levels of cortisol/stress.

Anti-inflammatory and antipyretic activities of B-sitosterol.

A basic research study using animal experiments was performed to determine whether sterols (plant fats) had any therapeutic properties such as reducing inflammation (anti-inflammatory), reducing fever (antipyretic) and reducing pain (analgesic). An extract of sterols from the seeds of the Indian herbal plant Cyperus rotundus was used in three separate experiments with rats to determine the medicinal properties. It was demonstrated that sterols possess potent anti-inflammatory properties similar to cortisone. Sterols were also demonstrated to reduce experimentally-produced edema. Sterols were also shown to have fever-reducing properties similar to aspirin (ASA). However, the sterols did not possess any pain-reducing or analgesic properties. In separate toxicology tests, sterols were shown to possess a very large margin of safety and produced minimal side effects such as gastric ulceration. The study concluded that sterols possess highly potent anti-inflammatory and antipyretic actions with a high margin of safety, suggesting its application to human medicine.

Ingredients

60 Capsules of 550mg of a proprietary blend consisting of 500mg of Glucosamine SO4 and 50mg of Phytosterols (Betasitosterol, Campesterol), pharmaceutical grade, standardised to 95% total sterols.

Directions

-ACUTE: 1 Capsule, 3 times daily.
-MAINTENANCE: 1 Capsule, twice daily