Product Information

Growth hormone mitigates, and may even reverse, many of the major effects of aging, such as muscle weakness, excess body fat deposits, poor skin and hair quality, energy depletion, diminished sex drive, and declining immune function.  Growth hormone stimulates the growth of organs that shrink with age:- the heart, liver, spleen, kidneys, thymus, and thyroid.  hGH stimulates production of insulin-like growth factor (IGF) which helps to optimise communication between the immune, nervous, and hormonal systems.  Growth hormone is responsible for tissue regeneration and youthful appearance.  The aging pituitary produces adequate growth hormone, but its release from the somatotroph cells is reduced with age.  Conversely, somatostatin, an inhibitor of growth hormone release, increases with age resulting in sub-optimil levels of growth-hormone from about the age of 40.  hGH Advanced Secretagogue represents the latest research into Growth Hormone Secretagogues, (pre-cursers and growth hormone releasing stimulants).  Research shows that the secretagogues contained in hGH-Advanced stimiulate the anterior pituity gland to release stored growth hormone.  Furthermore, only hGH-Advanced works in four ways to elevate growth hormone levels by: directly stimulating GH release, inhibiting somatostatin, enhancing the sensitivity of the pituity to Growth Hormone Releasing Hormone (GHRH) and increasing the secretion of GHRH. 

• Safely elevates Growth Hormone (GH) levels in 4-ways:

1. Stimulates GH release;
2. Inhibits Somatostatin;
3. Stimulates GHRH release;
4. Improves pituitary sensitivity;

• Opposes the physical appearance of aging:
• Enhances tissue regeneration and healing: organs, skin, hair, nails, lean muscle mass; fat-loss
• Improves mental function and immune response

What is hGH-advanced?

hGH-advanced is an upgrade of hGH Secretagogue, representing the latest research into Growth Hormone secretagogues (precursors and growth hormone releasing stimulants). Research shows that the sectretagogues contained in hGH-advanced stimulate the anterior pituitary gland to release stored growth hormone. Furthermore, only hGH-advanced works in four ways to elevate growth hormone levels by: directly stimulating GH release, inhibiting somatostatin, enhancing the sensitivity of the pituitary to Growth Hormone Releasing Hormone (GHRH), and increasing the sectretion of GHRH.

What is Growth Hormone, Somatostatin and Growth Hormone Releasing Hormone (GHRH)?
Growth Hormone-Releasing Hormone (GHRH) is produced and released by the hypothalamus. It directly stimulates the anterior pituitary to release growth hormone stored in specialised cells in the pituitary, called somatotrophs.

Growth hormone is responsible for tissue regeneration and youthful appearance. However, research has shown that, although the aging pituitary produces adequate growth hormone, its release from the somatotroph cells is reduced with age. Conversely, somatostatin, an inhibitor of growth hormone release, increases with age. The result is sub-optimal levels of growth-hormone from about the age of forty.

What are the benefits of Growth hormone?
Growth hormone mitigates, and may even reverse, many of the major effects of aging, such as muscle weakness, excess body fat deposits, poor skin and hair quality, energy depletion, diminished sex drive, and declining immune function.
In addition, Growth Hormone stimulates the growth of organs that shrink with age -the heart, liver, spleen, kidneys, thymus, and thyroid. Growth hormone stimulates production of insulin-like growth factor (IGF), which helps to optimise communication between the immune, nervous, and hormonal systems.

hGH-advanced uniquely works in all 4 ways to elevate Growth Hormone Levels by:
• Stimulating the somatotroph cells to release Growth Hormone.
• Stimulating the hypothalamus to produce Growth Hormone Releasing Hormone (GHRH)
• Enhancing the sensitivity of the pituitary to the effects of GHRH.
• Opposing the production and GH-suppressing effects of somatostatin

The principle behind the use of the multiple growth hormone releasing compounds contained in hGH-advanced is called “stacking”. This means that, since many of the compounds in hGH-advanced stimulate GH release by different mechanisms, taking them together causes a larger releasing effect. The doses of each can be made smaller than normally used, with fewer side effects. These compounds are synergistic when taken together, thereby increasing the effect beyond the additive amounts from each compound.

What does hGH-advanced contain and how does it work?
(per capsule - 722.34mg/per daily dose - 5779mg)

• Arginine aspartate, Lysine and Ornithine, are secretagogue amino acids that stimulate the release of growth hormone from the somatotroph cells in the anterior pituitary gland. Although arginine effectively elevates growth hormone release all by itself

1. Research by Professor Isidori at the University of Rome found that that the combination of arginine with lysine was 10 times more effective than arginine alone. Dr R. Klatz reports a four-fold increase in GH release with this combination, compared to arginine alone

• Ornithine hydrochloride: Only Ornithine hydrochloride, not ornithine alpha keto-glutarate (OKG) elevates growth hormone levels. In fact, although OKG is found in many Growth Hormone supplements, it actually DECREASES growth hormone levels and should be AVOIDED.

• Glutamine is the latest amino acid to generate excitement as a GH releaser, thanks to a 1995 study by Tomas C. Welbourne of Louisiana State University College of Medicine in Shreveport5. Welbourne showed that a surprising small oral dose of glutamine raised growth hormone levels more than four times, compared with subjects given a placebo. Even more exciting is that age did not diminish the response, since volunteers ages ranged from 32 to 64 years. This trial demonstrated that glutamine both enhances muscular protein synthesis and increases circulating growth hormone levels.

• Niacinamide form of vitamin B3, is a highly effective stimulator of Growth Hormone 6.

• Alpha GPC (glycerylphosphorylcholine) and Vitamin B5 (calcium pantothenate): Arginine, ornithine lysine and glutamine cause growth hormone release via the brain’s cholinergic nervous system. This system uses acetylcholine - made in the brain from the nutrient choline with the help of the cofactor vitamin B5 -to transmit information between the nerve cells. Alpha-GPC is the optimal form of choline for entering brain tissue. Without adequate amounts of acetylcholine, neither arginine, ornithine, lysine nor glutamine can cause growth hormone release. This is why it is essential to use of the optimal form of choline, alpha-GPC, combined with vitamin B5 in conjunction with arginine, ornithine, lysine and glutamine. Note: many antihistamines, cold/flu pills, and the non-prescription sedatives diphenhydramine and doxylamine are anticholinergics. These medicines will block the GH-releasing effects of arginine, ornithine, lysine and glutamine. Alpha-GPC also enhances the sensitivity of the pituitary gland to Growth Hormone Releasing Hormone (GHRH), thereby improving GHRH’s ability to stimulate the release of Human Growth Hormone (hGH)8. Alpha-GPC also increases the release of Gamma Aminobutyric Acid (GABA), an important GH releaser in its own right9.

• GABA (Gamma aminobutyric acid) increases Growth hormone release 10.

• Velvet bean Extract, contains 15% L-Dopa, which stimulates the secretion of Growth Hormone Releasing Hormone (GHRH), which in-turn stimulates the release of stored Growth Hormone 11.

Note: It is important that no vitamin B6 is taken at the same time as L-dopa, since vitamin B6 converts L-dopa into dopamine, in the body – and we want L-dopa to enter the brain to stimulate GHRH release, not to be destroyed by the body.

• Do not take anti-cholinergic medicines with hGH-advanced. Anti-cholinergic medicines include antihistamines, cold/flu pills, and the non-prescription sedatives diphenhydramine and doxylamine. These medicines will block the GH-releasing effects of arginine, ornithine, lysine and glutamine and will render hGH-advanced less effective.

• Do not take vitamin B6 (pyridoxine) at the same time as hGH-advanced since vitamin B6 converts the L-dopa contained in hGH-adavanced, into dopamine in the body. This is undesirable, since we want L-dopa to enter the brain to stimulate GHRH release, not to be destroyed by the body.

How is hGH-advanced unique?
• Contains the best form of arginine: arginine aspartate, not arginine hydrochloride or arginine pyroglutamate.

• Contains the best form of ornithine: ornithine hydrochloride, not ornithine alpha-ketoglutarate.

• Formulated with the optimal combination of arginine, ornithine, lysine and glutamine, essential for enhanced GH release.

• Works is four ways: GH release (secetagogues), GHRH release, anti-somatostatin and enhancing pituitary sensitivity to GHRH. Other products work in one way only, as secretagogues.

• Formulated according to the theory or stacking, also known as pharmacological synergy. This means that effectiveness is enhanced through the synergy of multiple mechanisms of action.

• Pyridoxine free (Pyridoxine opposes the GHRH releasing effects of L-Dopa)

• Uses the Niacinamide form of Vitamin B3, not the dangerous Xanthinol nicotinate form used in some other products.

• Glycine-free. Glycine is a neuro-excitatory amino acid that can be neuro-toxic.

References:
1. Ghigo, E., et al. Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects. J Endocrinol Invest. 17(2):113-117, 1994.).

2. Klatz, D.O., Ronald with Kahn, Carol, Grow Young with HGH (New York: 1997, HarperCollins Publishers, Inc.), pages 200, 201, 206, 304. ISBN 0-06-018682-8).

3. Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P; Increase in sleep related Growth Hormone after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). 1982 Jan;99(1):18-23).

4. Vaubourdolle M, Cynober L, Lioret N; Influence of ornithine alpha-ketoglutarate on hormonal patterns.

5. Welbourne TC. Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995;61:1058-61.

6. Kimura N, Kimura N, Cathala G, Baxter JD, Johnson GS; Nicotinamide and its derivatives increase growth hormone in cultured GH3 cells: role for ADP-ribosylation in modulating specific gene expression; DNA. 1983;2(3):195-203.

7. Casanueva, Villanueva, Cabranes, Cabezas-Cerrato, Fernandez-Cruz. Cholinergic mediation of growth hormone secretion elicited by arginine and physical exercise in man. J Clin Endocrin Metab 1984;59(3): 526-30).

8. Ceda, G. P., et al. Glyceryl-phosphorylcholine administration increases the growth hormone responses to GHRH of young and elderly subjects. Horm Metabolism Res. 24(3):119-121, 1992).

9. Ferraro, L., et al. Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine. Neurochem Res. 21(5):547-552, 1996).

10. Cavagnini F, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone secretion in man. Acta Endocrinol (Copenh) 1980;93(2):149-54.

11. Hanew, K., et al. The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH release in normal subjects. Eur J Endocrinol. 146(2):197-202, 2002.

12. Pardo, B., et al. Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line. Mov Disorder. 8(3):278-284, 1993

* * * * *