Product Information

Is a sulfur-containing molecule found in various plants and some body tissues. It is a natural and efficient source of the sulfur that is used by many of the body's structural molecules. The body's content of MSM declines in tandem with the progression of the Aging Process. MSM is useful for inflammation and pain relief.

Health Benefits of MSM

Aging Process

The body’s content of MSM appears to decline in tandem with the progression of the Aging Process.
MSM may inhibit the Cross-Linking of the body’s endogenous Proteins (Cross-Linking of Proteins such as Collagen is a major aspect of the Aging Process).

Cardiovascular System

MSM may improve Blood Circulation.

Detoxification

MSM is claimed to rapidly (within twenty minutes of ingestion) alleviate the symptoms of Hangovers (according to anecdotal reports).

Digestive System

MSM (500 2,000 mg per day) may prevent and treat Constipation (especially Constipation in elderly persons).
MSM (3,000 mg per day) may alleviate Heartburn.
MSM (3,000 10,000 mg per day) may prevent Intestinal Parasites from adhering to the Gastrointestinal Tract and may thereby facilitate the expulsion of Intestinal Parasites from the body:

MSM may be an effective treatment for Roundworms (Nematodes).

MSM is claimed to prevent and treat Intestinal Permeability (MSM is claimed to coat the Mucous Membranes of the Intestines, preventing Antigens from entering the Bloodstream through the Intestinal Wall).

Ears/Hearing

MSM (instilled into the Ears via MSM eardrops) is claimed to alleviate Age Related Hearing Loss (according to many anecdotal reports).
MSM (instilled into the Ears via MSM eardrops) is claimed to alleviate Tinnitus (according to many anecdotal reports).

Excretory System

MSM (as a constituent of Toothpaste or Mouthwashes) may alleviate Halitosis.
MSM may be an effective treatment for Interstitial Cystitis.

Eyes/Vision

MSM (applied topically as eyedrops) may alleviate Bloodshot Eyes.
MSM (applied topically as eyedrops) may reduce intraocular pressure in Glaucoma patients.

Immune System

MSM (3,000 6,000 mg per day) may help to prevent and alleviate Allergies (including long-standing Food Allergies and Respiratory System Allergies).
MSM may help to prevent Autoimmune Diseases:

MSM may help to prevent and treat Lupus Erythematosus (SLE form).

MSM may help to prevent Breast Cancer.
MSM may help to prevent Colon Cancer.
MSM may help to prevent the Common Cold.
MSM (consumed orally) may inhibit some types of Detrimental Fungi and MSM (lotion applied topically) may destroy many types of Detrimental Fungi that reside on the Skin including:

Histoplasma capsulatum

MSM may inhibit some types of Detrimental Protozoa including:

Entamoeba histolytica (especially when MSM is used concurrently with Cat’s Claw).
Giardia lamblia (which causes Giardiasis)
Trichomonas

MSM may reduce Inflammation.
MSM may help to prevent Influenza.

Metabolism

MSM may inhibit the Cross-Linking of the body’s endogenous Proteins (Cross-Linking of Proteins such as Collagen is a major aspect of the Aging Process).
MSM may alleviate Diabetes Mellitus (by facilitating the endogenous production of Insulin and by decreasing Insulin Resistance).

MSM (4,000 mg per day) may reduce the toxic accumulation of Lactic Acid following Exercise and may accelerate the recovery from Exercise.
MSM is claimed to alleviate Fatigue.
MSM may decrease Insulin Resistance (by increasing the permeability of Cells which may cause them to become more responsive to the actions of Insulin).

Musculoskeletal System

MSM may alleviate the Pain and Inflammation associated with Bursitis.
MSM (consumed orally and/or lotion applied topically) may reduce the Inflammation and Pain associated with Carpal Tunnel Syndrome.
MSM may enhance the health of the body’s Cartilage (by contributing its Sulfur content to Cartilage).

MSM (consumed orally and/or lotion applied topically) may alleviate the Pain and Inflammation associated with Epicondylitis.
MSM may accelerate the healing of Fractures (according to anecdotal reports).
MSM may be a useful treatment for some of the symptoms of Fibromyalgia.

MSM may alleviate the Pain and Inflammation of the Joints that is associated with Gout (but may require several weeks of daily supplementation before its beneficial effects become apparent).
MSM may improve the function of the Joints and alleviates Joint Pain.
MSM may concentrate in Mucous Membranes.

MSM (especially when combined with supplemental Vitamin C) may alleviate Muscle Cramps.
MSM may alleviate Muscle Pain.
MSM (2,250 mg per day) may alleviate Osteoarthritis (by improving the integrity of Cartilage and Joints).

MSM has been reported anecdotally to cure some cases of Polymyalgia Rheumatica.
MSM may alleviate the Pain and Inflammation associated with Rheumatism.
MSM may alleviate the Pain and Inflammation associated with Rheumatoid Arthritis and may inhibit the further degeneration of Cartilage in Rheumatoid Arthritis patients.

MSM may alleviate the Pain and Inflammation associated with Tendonitis.
MSM (consumed orally and/or lotion applied topically) may alleviate the Pain and Inflammation associated with Tennis Elbow.

Nervous System

MSM (3,000 9,000 mg per day) may increase Alertness.
MSM (3,000 9,000 mg per day) may alleviate Anxiety.
MSM (rarely) may alleviate Migraines.
MSM (3,000 9,000 mg per day) may increase Concentration ability.

MSM (3,000 9,000 mg per day) may improve Mood.
MSM may alleviate Nausea.
MSM may alleviate Pain (it is speculated that MSM may inhibit the transmission of Nerve Impulses associated with Pain).
MSM (16% water-soluble solution of MSM administered to each nostril 15 minutes prior to Sleep) may reduce Snoring in chronic Snoring sufferers.

MSM may minimize the toxic effects associated with excessive Stress.

Oral Health

MSM (as a constituent of Mouthwash or Toothpaste) may alleviate Gingivitis.

Respiratory System

MSM may alleviate Asthma (where Asthma is caused by Allergies).
MSM is claimed to reverse Emphysema (according to some physicians’ observations) and supplemental MSM may improve walking distance in Emphysema patients.
MSM (2,600 mg per day) may reduce the symptoms of Hay Fever.

Sexual System

MSM (3,000 5,000 mg per day orally or MSM cream applied topically to the Penis) is claimed to be useful for the treatment of Peyronie’s Disease.
MSM is claimed to alleviate the Headaches associated with (the PMS-C form of) Pre-Menstrual Syndrome (PMS) (according to anecdotal reports).

Skin/Hair/Nails

MSM (consumed orally or lotion applied topically) may alleviate Acne.
MSM (lotion applied topically) may alleviate Dry Skin.
MSM (administered orally) may improve Hair Condition.
MSM (administered orally) may increase Hair Growth and may therefore be useful for persons experiencing Hair Loss.

MSM (lotion applied topically) may alleviate Insect Bites/Stings and many people who consume oral MSM report milder reactions to subsequent Insect Bites/Stings.
MSM (administered orally or lotion applied topically) may minimize the Itching associated with Insect Bites/Stings and contact with Poison Ivy and Poison Oak.

MSM (administered orally) may facilitate the growth of Nails (due to its Sulfur content).
MSM (lotion applied topically) may alleviate Psoriasis.
MSM (lotion applied topically) may alleviate Rashes.
MSM (consumed orally or lotion applied topically) may alleviate Rosacea.

MSM (applied topically or consumed orally) may help to prevent Scarring and may eliminate some existing Scars.
MSM may “soften” the Skin of Scleroderma patients and may restore a significant amount of elasticity to the Skin of Scleroderma patients.
MSM (lotion applied topically) may alleviate the lesions associated with Shingles.

MSM (administered orally or lotion applied topically) may help to prevent the undesirable Cross-Linking of the Collagen content of the Skin (Cross-Linking of the Skin’s Collagen content is associated with Wrinkles). MSM also increases the elasticity of the Skin.
MSM (500 2,000 mg per day consumed orally or lotion applied topically) may alleviate Sunburn.

MSM may accelerate the healing of Wounds.

MSM may Enhance the Function of these Substances

Amino Acids

MSM contributes its Sulfur component to Methionine and (to a lesser extent) Cysteine.

Carbohydrates

MSM contributes its Sulfur component to Chondroitin Sulfate (CSA).

Hormones

MSM may facilitate the production of Insulin (by domating its Sulfur content to Insulin).

Immune System Chemicals

MSM contributes its Sulfur component to IgG.

Minerals

MSM provides a highly bioavailable source of Sulfur to the body (Sulfur is utilized in the production of, and is a component of, many endogenous compounds of the body):

Elemental Sulfur comprises 34% of the MSM molecule.
Vitamin C facilitates the conversion of supplemental MSM to endogenous Sulfur.

Proteins

MSM may facilitate the formation of Collagen (by donating its Sulfur content to Collagen):

MSM may inhibit the (undesirable) Cross-Linking of the body’s Collagen content.

MSM contributes its Sulfur component to Keratin (Keratin Sulfate).

Sulfuric Compounds

MSM is believed to be the active therapeutic constituent of Dimethyl Sulfoxide (DMSO).

MSM may Reduce the Toxic Effects of these Substances

Minerals

MSM may facilitate the removal of Aluminium from the body.
MSM may facilitate the removal of Mercury from the body.

Organic Acids

MSM may reduce the accumulation of Lactic Acid following Exercise.

These Substances may Enhance the Function of MSM

Vitamins

The therapeutic effects of MSM are enhanced by the concurrent use of 2,000 mg of supplemental Vitamin C per day (Vitamin C is essential for the metabolism of exogenous MSM to endogenous Sulfur).

Dietary Sources of MSM

MSM is a constituent of raw Fruits, Vegetables (especially Cruciferous Vegetables), Seafoods, Meat and Milk. It is extremely volatile and is highly susceptible to loss and degradation during Food Processing. Most people do not ingest significant amounts of MSM from Food (unless the diet is composed primarily of raw Foods).

(mg of MSM per 100 grams)

Dairy Foods: Milk (cow’s) 0.33
Herbs: Tea 0.03 Alfalfa trace
Horsetail trace
Processed Foods: Coffee 0.16
Vegetables: Tomatoes 0.086 Swiss Chard 0.005
Corn 0.011
MSM as part of the Global Sulfur Cycle

MSM is the stable end product of the methyl-S-methane global Sulfur cycle which distributes bioavailable Sulfur for all animal and plant life. Approximately 85% of Sulfur (for life) is derived from the pathway:

Sulfonium Salts > Dimethylsulfide > Dimethyl Sulfoxide (DMSO) > Methylsulfonylmethane (MSM)
Sulfonium Salts (produced by phytoplankton in Water) yield the volatile thioether named Dimethylsulfide which is released into the upper atmosphere.
Sunlight catalyzes the oxidation of Dimethylsufide to DMSO.
DMSO is further oxidized in the upper atmosphere (by Sunlight) to form MSM.
This MSM is then concentrated into raindrops which return to the surface of the earth.

Plants absorb and accumulate this MSM (and use some of this MSM for bulding Sulfuric compounds).

Safety of MSM

The LD 50 of MSM is so high that it has not yet been determined (its safety is similar to that of Water):

Rabbits fed up to 20 grams of MSM per kg of body weight have a 100% survival rate.
Primates whose Blood levels of MSM were maintained at greater than 1 gram per kg of body weight for two years were free of any toxic effects.
Human subjects administered 500 mg of MSM per kg of body weight (intravenous administration) for six successive days experienced no measurable toxicity.

No allergic reactions have ever been associated with human MSM use.
There are no known contraindications to MSM use.

Bioavailability

Ingested MSM enters almost all tissues of the body within 24 hours of its oral ingestion.
Most unused or metabolized MSM is excreted from the body within 96 hours of its ingestion (although some MSM remains in the body for up to 400 hours (16 days) after its ingestion.
The half-life of MSM is approximately 38 hours.

MSM is excreted from the body primarily via the Urine. Lesser amounts are excreted via Saliva, exhaled air and Perspiration.
MSM remains within the body for a longer period than its “sister” compound DMSO.
MSM is capable of crossing the Blood-Brain Barrier.

Dosage Recommendations

General Therapeutic Dosage

The minimum effective dosage of supplemental oral MSM is 750 1,500 mg per day.
The optimal dosage of supplemental MSM is presently regarded as 2,000 6,000 mg per day.
The usual therapeutic dosage of supplemental MSM for the alleviation of Pain is 2,250 mg per day.

Toxic Dosage

Doses of up to 30,000 mg (30 grams) of MSM have been used on a daily basis without adverse effects occurring.

“Waiting Period”

Most people who use supplemental MSM do not notice any therapeutic effects until they have used MSM on a daily basis for several days. Some people do not experience therapeutic effects until MSM has been used daily for several weeks.