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Product Information A specific form of Vitamin B3, Useful as a life-extension agent and retards the Aging Process. Converts to NAD and plays a central role in controlling the aging process and Gene Silencing. Health Benefits of Niacinamide
The health benefits of Niacinamide are generally representative of those listed for Vitamin B3 other health benefits of Niacinamide are listed in the topic for Vitamin B3.PROPRIETARY NAME (and dosage form): Nicotinamide (specific form of vitamin B3) (capsules) COMPOSITION: Each capsule contains the following as active ingredient: Nicotinamide...........................................................500 mg Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell (gelatin free), microcrystalline cellulose, magnesium stearate (vegetarian flow agent), magnesium silicate, silicon dioxide and colloidal silicon dioxide. Contains no colourants, preservatives, lactose, gluten, yeast, starch or artificial fillers. Contains plant extracts and natural fillers, with no colourants added - therefore the colour of the capsule contents may vary slightly from batch to batch. PHARMACOLOGICAL ACTION: Nicotinamide is a precursor of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which is essential for oxidation-reduction reactions, ATP synthesis, and ADP-ribose transfer reactions. Nicotinamide prevents or delays insulin deficiency in laboratory models of type 1 diabetes. However, nicotinamide can also increase insulin resistance, although to a lesser extent than niacin. Mechanisms of beta-cell protection by nicotinamide might include inhibition of poly (ADP-ribose) polymerase which is activated during toxin-induced beta-cell damage, scavenging of oxygen radicals and nitric oxide which cause cell lysis, restoration of intracellular NAD pools, alteration of auto-immune processes including reducing expression of major histocompatibility complex class II and gamma-interferon-induced intracellular adhesion molecule 1 on endothelial cells, and blocking the effects of interleukin-1. Nicotinamide is hypothesized to inhibit induction of nitric oxide synthase by interleukin 1 in chondrocytes, reducing inflammation and leading researchers to speculate about its potential use in destructive joint diseases. In vitro, nicotinamide inhibits the activity of sirtuins, NAD(+)- dependent protein deacetylases involved in transcriptional regulation, metabolism, apoptosis, differentiation and aging. Li et al. has reviewed the role of mitochondrial membrane potential, poly (ADP-ribose) polymerase, protein kinase B (Akt), Forkhead transcription factors, caspases, and microglial activation in the role of nicotinamide and cellular integrity and longevity. Each of these cellular targets may play a role in nicotinamide-induced anti-aging effects in the cell. INDICATIONS: Nicotinamide is a specific form of vitamin B3 also known as niacinamide. It opposes four bio-chemical pathways thought to accelerate the aging process. Nicotinamide converts to NAD (nicotinamide adenine dinucleotide) and plays a central role in controlling the aging process and gene silencing. Note that although nicotinamide is a form of vitamin B3, it will not reduce cholesterol levels, unlike the other form of vitamin B3, niacin. Nicotinamide will not cause skin flushing, whereas niacin will. Preliminary evidence shows that pharmacological doses of nicotinamide may assist in the management of diabetes. Nicotinamide is also useful for skin and brain health. WARNINGS: Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Safety in children has not been established. INTERACTIONS: Allupurinol and gout medications: Large doses of nicotinamide could potentially reduce the excretion of uric acid. Doses of uricosuric medications such as allopurinol may need to be increased. Antidiabetic medicines: Nicotinamide impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. Carbamazepine: High doses of nicotinamide may lead to an increase in carbamazepine blood levels. HMG CoA Reductase Inhibitors (statins): There is concern that nicotinamide might increase the risk of myopathy when combined with statins. Use this combination with caution. Statin medicines include atorvastatin, fluvastatin, lovastatin, pravastatin and simvastatin. PREGNANCY AND BREASTFEEDING: Safety during pregnancy and breastfeeding has not been established, do not use. DOSAGE AND DIRECTIONS FOR USE: Adults and children over 12 years of age: Take 1-2 capsules twice daily or as recommended by your health care provider. SIDE EFFECTS AND SPECIAL PRECAUTIONS: Side effects: Side effects are rare, but include nausea, bloating, flatulence, hunger pains, vomiting, heartburn, diarrhoea, dizziness. Very high doses might cause jaundice and elevated serum transaminases. Such high doses should be discontinued if liver function tests rise to three times the upper limit of normal. Special precautions: Allergies: Nicotinamide may exacerbate allergies by causing histamine release. Diabetes: Nicotinamide can interfere with blood glucose requiring an adjustment of antidiabetic agents. Gout: Large amounts of nicotinamide can precipitate gout. Peptic ulcer disease: Large amounts of nicotinamide might activate peptic ulcer disease. Surgery: Nicotinamide might affect blood glucose levels. Nicotinamide may interfere with blood glucose control during and after surgery. Individuals should discontinue 2 weeks before elective surgical procedures. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Treatment should be symptomatic and supportive. In the case of accidental overdose of the product, contact the nearest hospital or poison control centre. IDENTIFICATION: Clear vegetarian capsule shell (size 0) containing white contents. PRESENTATION: White HDPE container with white HDPE screw cap and seal for protection. Containing 90 capsules. STORAGE INSTRUCTIONS: Store in a cool dry place, keep out of the reach of children.
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