A Powerful and Natural Cancer-Fighting Substance, Inducing Multi-Faceted Biological Effects including: Curcumin is a valuable treatment for Acquired Immune Deficiency Syndrome (AIDS) patients: Curcumin helps to prevent the development of and inhibits the further growth of some forms of Cancer. Curcumin possesses potent Antioxidant properties: Curcumin lowers total serum Cholesterol levels, enhances the function of the Liver. Curcumin is equally as effective as (and less expensive than) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the treatment of inflammation and the various ailments associated with Inflammation: Curcumin potently stimulates the Immune System: Curcumin counteracts the Brain damage caused by Alcohol (ethanol). Curcumin protects against Lung damage caused by various toxic substances.
Curcumin is a type of Phenolic Acid Curcuminoid that is a derivative of Cinnamic Acid. It is soluble in Alcohol and Oils.
Health Benefits
Mellitus Type 2 patients:Immune System
Curcumin may be a valuable treatment for Acquired Immune Deficiency Syndrome (AIDS) patients:
- Curcumin may inhibit the Integrase enzyme that catalyzes part of the process involved in the replication of the HIV virus. - Curcumin may interfere with the Long Terminal Repeat (LTR) sequence of the HIV virus. - Curcumin may increase the Helper T-Cell count of Acquired Immune Deficiency Syndrome (AIDS) patients - in one study the oral administration of 2,000 mg of Curcumin per day to AIDS patients for 20 weeks resulted in an increase in average Helper T-Cell counts from 6 - 615 cells per ml of blood to 283 - 1,467 cells per ml of blood.
Curcumin may help to prevent the development of and inhibits the further growth of some forms of Cancer.
- Curcumin may stimulate the Apoptosis (cellular “suicide”) of some types of Cancer cells. - Curcumin may help to prevent Bladder Cancer. - Curcumin may help to prevent Breast Cancer. - Curcumin may help to prevent Colon Cancer. - Curcumin may help to prevent Duodenal Cancer.
- Curcumin may cause the Apoptosis (death) of the Cancer Cells involved in the Acute Promyelocytic Leukemia form of Leukemia:
- Curcumin may be useful for the treatment of Chronic Myelogenous Leukemia.
- Curcumin may help to prevent Liver Cancer (including Nitrosamines-induced Liver Cancer). - Curcumin may help to prevent Lung Cancer. - Curcumin may inhibit the metastasis of Melanoma. - Curcumin may help to prevent Mouth Cancer:
- Curcumin may help to prevent Tongue Cancer.
- Curcumin may inhibit the growth of Pancreatic Cancer. - Curcumin may help to prevent and treat Prostate Cancer. - Curcumin (applied topically or ingested orally) helps to prevent carcinogen-induced Skin Cancer. - Curcumin may help to prevent Stomach Cancer. - One of the means by which Curcumin exerts its anti-Cancer properties is by stimulating the p53 Tumor Suppressor Gene to produce the p53 Protein.
Curcumin may inhibit Helicobacter pylori. Curcumin may stimulate various aspects of the Immune System:
- Curcumin may increase the production of Antibodies. - Curcumin may enhance the ability of Macrophages to function as Phagocytes. - Curcumin may increase the body’s production of White Blood Cells.
Curcumin may be equally as effective as (and less expensive than) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for the treatment of Inflammation and the various ailments associated with Inflammation:
- Curcumin’s mechanism of action in the suppression of Inflammation is believed to be via increasing the endogenous secretion of Cortisol; increasing the sensitivity of Glucocorticoid Receptors to Cortisol; and increasing the half-life of endogenous Cortisol by retarding its degradation within the Liver. - Curcumin may reduce the Inflammation that usually occurs following Surgery.
Curcumin may help to prevent Leukoplakia from progressing to Mouth Cancer.
Metabolism
Curcumin possesses potent Antioxidant properties:
- Curcumin quenches Singlet Oxygen Free Radicals. - Curcumin scavenges Peroxynitrite Free Radicals. - Curcumin has been shown to be equal in Antioxidant potency to Butylated Hydroxyanisole (BHA).
Curcumin may lower total serum Cholesterol levels:
- Curcumin may increase HDL Cholesterol levels by up to 29%. - Curcumin may lower LDL Cholesterol levels. Curcumin may also inhibit the oxidation of LDL Cholesterol.
Curcumin may reduce the Kidney damage (diabetic Nephropathy) that occurs in Diabetes Mellitus patients:
- Curcumin may reduce the Kidney damage (diabetic Nephropathy) that occurs in Diabetes Mellitus Type 1 patients. - Curcumin may reduce the Kidney damage (diabetic Nephropathy) that occurs in Diabetes Mellitus Type 2 patients.
Curcumin enhances the function of the Liver:
- Curcumin exerts Antioxidant effects in the Liver. - Curcumin may help to reverse the Liver damage caused by Aflatoxin. - Curcumin may help to prevent Cirrhosis. - Curcumin may suppress the damage to Liver cells (hepatocytes) caused by Hepatitis C. - Curcumin may stimulate the production of Glutathione by the Liver. - Curcumin may inhibit the deposition of Triglycerides in the Liver.
Curcumin may lower total serum Triglycerides levels and may inhibit the deposition of Triglycerides in the Liver.
Musculoskeletal System
Curcumin (1,200 - 2,600 mg per day) may alleviate the Inflammation associated with Rheumatoid Arthritis. It may also reduce morning stiffness and increases walking time in Rheumatoid Arthritis patients. Part of this effect occurs from Curcumin inhibiting the Cyclooxygenase-2 (COX-2) enzyme. Curcumin may help to prevent/treat Scleroderma.
Nervous System
Curcumin may help to prevent and treat Alzheimer’s Disease (due to the ability of Curcumin to counteract the toxic effects of Amyloid-Beta Protein). Curcumin may be useful for the prevention or treatment of Bovine Spongiform Encephalopathy (BSE) (Mad Cow Disease). Curcumin may counteract the Brain damage caused by Alcohol (ethanol). Curcumin may inhibit the further progression of Multiple Sclerosis (MS).
Respiratory System
Curcumin may protect against Lung damage caused by various toxic substances. Skin
Curcumin (applied topically or consumed orally) may alleviate Psoriasis (by inhibiting the inflammatory Eicosanoids that contribute to Psoriasis and by lowering elevated levels of Phosphorylase kinase). Curcumin (consumed orally or applied topically) may accelerate the healing of Wounds.
Curcumin may Enhance the Function of these Substances
Immune System Chemicals
Curcumin may stimulate the production of Interleukin 4.
Lipids
Curcumin may enhance the secretion of Prostaglandin F1 alpha.
Peptides
Curcumin may stimulate the production of Glutathione by the Liver.
Polyphenols
Curcumin is synergistic with Epigallo-Catechin-Gallate (EGCG) (in terms of the ability of EGCG to prevent Mouth Cancer).
Curcumin may Counteract these Potentially Toxic Substances
Amines
Curcumin may reduce the toxicity of Heterocyclic Aromatic Amines (HAAs). Curcumin may inhibit the ability of Nitrosamines to cause Liver Cancer. Enzymes
Curcumin may inhibit the Cyclooxygenase-2 (COX-2) enzyme. Curcumin may inhibit the Integrase enzyme that catalyzes part of the process involved in the replication of the HIV virus. Curcumin may inhibit Ornithine Decarboxylase (an enzyme that is implicated in various types of Cancer).
Curcumin may inhibit Protein Kinase C.
Hormones
Curcumin may inhibit Platelet Aggregating Factor (PAF).
Lipids
Curcumin may inhibit Leukotriene B4. Curcumin may inhibit Leukotriene C4. Curcumin may inhibit Prostaglandin E2 (PGE2). Curcumin may inhibit Thromboxane A2 (TXA2).
Microorganisms
Curcumin may help to reverse the Liver damage caused by Aflatoxin. Minerals
Curcumin may help to prevent Lead-induced Brain damage.
Pesticides
Curcumin may partially block the toxicity of Dioxin (Curcumin competes with Dioxin for binding to the Aryl Hydrocarbon Receptor - however Dioxin is a more potent Aryl Hydrocarbon Receptor compared to Curcumin and therefore Curcumin can only partially block the effects of Dioxin). Pharmaceutical Drugs
Curcumin may minimize the toxic effects of Doxorubicin on the Heart and Kidneys. Proteins
Curcumin may inhibit the neurotoxic effects of Amyloid-Beta Protein. Curcumin may help to lower elevated C-Reactive Protein levels. Curcumin may inhibit Nuclear Factor-Kappa B. Recreational Drugs
Curcumin may counteract the Brain damage caused by Alcohol (ethanol). Curcumin may inhibit the ability of Tobacco to cause various types of Cancer (especially Lung Cancer).
These Substances may Enhance the Function of Curcumin
Amides
Piperine (Bioperin) may increase the oral bioavailability of Curcumin (by 2,000% (twenty-fold).
Enzymes
Bromelain may enhance the oral bioavailability of Curcumin. Papain may enhance the oral bioavailability of Curcumin. Dietary Sources of Curcumin
Curcumin is poorly absorbed when administered orally (this accounts for the relatively high therapeutic doses that are employed by researchers investigating Curcumin):
If Curcumin is ingested orally at the same time as a high fat meal, its oral absorption is increased.When consumed orally, serum levels of Curcumin peak at one to two hours after Curcumin intake. Serum levels of Curcumin then gradually decline over a period of 12 hours. Other Forms of Curcumin
Sodium Curcuminate is a more potent form of Curcumin than standard Curcumin.
Dosage Recommendations
The general therapeutic dosage of Curcumin for healthy persons seeking to prevent Cancer is 900 - 1,800 mg per day. The recommended dosage of Curcumin for Cancer patients (who seek to “kill” their tumors via apoptosis) is 2,000 - 8,000 mg per day. The effective dosage of Curcumin for Rheumatoid Arthritis patients is 1,200 - 2,600 mg per day.
