The oral absorption of Magnesium Glycinate is regarded as excellent. Magnesium improves the function of the Adrenal Glands. Magnesium is involved in the health of Bones (64% of the body's Magnesium is concentrated in the Bones). Magnesium deficiency increases the risk of developing all forms of Cancer and increases the mortality rate from Cancer. It assists with Mood, Cholesterol, and Diabetes. Prostrate disorders are a symptom of Magnesium Deficiency. This product will deliver the correct amounts of Calcium and Magnesium and in the ideal ratios of 2 to 1 and is a full 1 month supply. Other products may be sufficient for only 10 to 15 days.
This section outlines the biological function and therapeutic applications of Magnesium.
Health Benefits of Magnesium
Abnormally low circulating Blood levels of Magnesium is known as Hypomagnesemia.
Magnesium may improve the function of the Adrenal Glands.
Magnesium may modulate the electrical potential of Cell Membranes and may help to maintain the permeability of Cell Membranes:
- Magnesium may help to maintain the proper electrical charge gradient across Cell Membranes.
Magnesium Sulfate (Epsom Salts) is a good laxative for Constipation (it reduces the normal absorption of Water from the Intestine, thereby causing Bowel Movement). Diarrhea may occur as a symptom of Magnesium deficiency and Diarrhea may cause the excessive excretion of Magnesium.
Magnesium may alleviate some cases of Heartburn.
Nausea may occur as a symptom of Magnesium deficiency.
Vomiting may occur as a symptom of Magnesium deficiency.
Ears and Hearing
Magnesium may help to prevent some types of Deafness:
- Magnesium (especially the Magnesium Aspartate form) may help to prevent Noise-Induced Hearing Loss.
- Oversensitivity to Noise may occur as a result of Magnesium deficiency. Vomiting may occur as a symptom of Magnesium deficiency.
Magnesium may strengthen the Bladder Muscles.
Magnesium may help to remove the substances that cause Body Odor from the body.
Magnesium may alleviate Incontinence by strengthening the Bladder muscles within three months of initial supplementation.
Magnesium Phosphate and Magnesium Sulfate (Epsom Salts) have been used as traditional remedies for alleviating Foot Odor.
Magnesium may reduce Inflammation of Kidney tissues.
Magnesium (400 - 600 mg per day) may inhibit Calcium Oxalate crystal formation in the Urine (Magnesium increases the solubility of Calcium Oxalate) and may thereby help to prevent Calcium Oxalate Kidney Stones:
- - Calcium Oxalate Kidney Stones are most likely to form in people who are deficient in Magnesium.
- - The Urine of people who are prone to Calcium Oxalate Kidney Stones usually has a lowered Magnesium:Calcium ratio.
- - Magnesium supplementation may be effective for preventing the reappearance of Calcium Oxalate Kidney Stones in persons who have previously had Kidney Stones.
Magnesium may alleviate or prevent Dry Eyes (due to its role in the production of Prostaglandin E7, a compound that is necessary for tear production).
Magnesium (243 mg per day for at least one month) may improve the visual field and peripheral Blood Circulation of Glaucoma patients:
- Magnesium help to prevent Glaucoma (by counteracting the toxicity of Glutamic Acid, a suspected cause of Glaucoma).
Magnesium may be essential for the development and maintenance of the Optic Nerve.
Magnesium may be essential for the optimal function of the Retina.
Many (59% of) Acquired Immune Deficiency Syndrome (AIDS) patients are found to be deficient in Magnesium and supplemental Magnesium may help to prevent the loss of Helper T-Cells in AIDS patients.
Magnesium deficiency may increase the risk of developing some forms of Cancer and Magnesium deficiency may increase the mortality rate from Cancer:
- - Magnesium may help to prevent Liver Cancer.
- - Magnesium may help to prevent Mouth Cancer (oral Cancer).
Fever may occur as a symptom of Magnesium deficiency.
Chronic Magnesium deficiency may cause abnormalities in the development of the Lymph Nodes.
Magnesium deficiency may impair the ability of Macrophages to function as Phagocytes.
Chronic Magnesium deficiency may cause abnormalities in the development of the Spleen.
Systemic Lupus Erythematosus (SLE) patients often exhibit abnormally low Magnesium levels.
Chronic Magnesium deficiency may cause abnormalities in the development of the Thymus.
Metabolism: Blood Sugar
Magnesium may help to prevent Diabetes Mellitus and may help to keep Diabetes Mellitus under control (most Diabetes Mellitus patients are found to be deficient in Magnesium).
- - Magnesium supplementation may reduce the requirement for exogenous Insulin in Diabetes Mellitus Type 1 patients.
- - Deficient levels of intracellular Magnesium may contribute to the impaired Insulin response that occurs in Diabetes Mellitus Type 2.
- - Diabetes Mellitus patients may have a greater risk of (diabetic) Retinopathy if they are deficient in Magnesium than Diabetes Mellitus patients who are not deficient in Magnesium.
Hypoglycemia may occur as a result of Magnesium deficiency.
Insulin Resistance may occur as a result of Magnesium deficiency.
Magnesium may improve Athletic Performance (via ATP production).
Magnesium may facilitate the conversion of endogenous Glucose (blood sugar) into Energy (due to its role in the production of Adenosine Triphosphate (ATP)).
Magnesium (Magnesium Aspartate form combined with Potassium Aspartate) may increase the capacity for prolonged Exercise (by up to 50%):
- - Supplemental Magnesium may counteract the accelerated excretion of Magnesium that occurs in people who engage in Endurance Exercise.
- - Magnesium may prevent Exercise-induced increases in Aldosterone and Cortisol levels.
Magnesium (especially the Magnesium Aspartate form of Magnesium when combined with Potassium Aspartate) may alleviate Fatigue (due to its role in the manufacture of Adenosine Triphosphate (ATP)). Magnesium supplementation may reduce the next-day Fatigue associated with Insomnia.
- - Magnesium (especially the Magnesium Aspartate form of Magnesium - 1,000 mg per day) may alleviate Chronic Fatigue Syndrome (CFS).
Lethargy may occur as a result of Magnesium deficiency.
Magnesium may increase Stamina (Magnesium deficiency may result in lowered Stamina).
Magnesium (especially the Magnesium Aspartate form) may lower total serum Cholesterol levels and elevated total serum Cholesterol levels may occur as a symptom of Magnesium deficiency:
- - Magnesium may increase HDL Cholesterol levels.
- - Magnesium may lower serum LDL Cholesterol levels and may inhibit the oxidation of LDL Cholesterol.
Magnesium may help to lower elevated serum Triglycerides levels (where elevated serum Triglycerides occur as a result of Cholesterol loading).
Cirrhosis may occur as a result of Magnesium deficiency. Cirrhosis patients often have low Magnesium levels.
Magnesium deficiency may increase the body's susceptibility to Hepatitis infection.
Metabolism: Thyroid & Parathyroid
Some cases of Hyperparathyroidism may be attributable to Magnesium deficiency and supplemental Magnesium may alleviate such cases.
Hyperthyroidism may occur as a result of Magnesium deficiency.
Magnesium may facilitate weight loss in persons afflicted with Obesity (due to its role in the production of Adenosine Triphosphate (ATP)).
Musculoskeletal System: Bones
Magnesium is involved in the health of Bones (64% of the body's Magnesium is concentrated in the Bones).
Magnesium may help to prevent Fractures (due to its ability to increase Bone Mineral Density).
Magnesium deficiency may result in increased Osteoclast activity.
Osteoporosis may occur as a result of Magnesium deficiency - women afflicted with Osteoporosis have been shown to have significantly lower Bone Magnesium than healthy women.
Paget’s Disease may cause low serum Magnesium levels (due to higher uptake of Magnesium into Bone). Therefore, Magnesium supplementation may be warranted for Paget’s Disease patients in order to avoid Magnesium deficiency.
Musculoskeletal System: Muscles
Magnesium may help to reverse Cachexia (by enhancing the synthesis of endogenous Proteins and by restoring optimal production of Insulin-like Growth Factor-1 (IGF-1)).
Magnesium may prevent Convulsions and Convulsions may occur as a result of Magnesium deficiency.
Magnesium deficiency within Muscle cells is speculated to be a factor in the development of Fibromyalgia:
- - Daily supplementation of 300 - 600 mg of Magnesium (especially from the Magnesium Malate form) may result in significant improvements in the number of tender points in Fibromyalgia patients.
- - Some researchers speculate that this improvement results from the Malic Acid content of Magnesium Malate rather than the Magnesium content, although there is also evidence that Magnesium may contribute significantly to the effectiveness of Magnesium Malate.
Magnesium may alleviate Muscle Cramps and Muscle Cramps may occur as a result of Magnesium deficiency:
- - Magnesium may alleviate the Muscle Cramps (leg Cramps) that often occur during Pregnancy.
Supplemental Magnesium (560 mg per day) may increase Muscle Strength.
Muscle Tension may occur as a result of Magnesium deficiency and supplemental Magnesium may alleviate Muscle Tension:
- - Magnesium is responsible for the effectiveness of Epsom Salts (added to bath water) for alleviating Muscle Tension.
Muscle Weakness may occur as a result of Magnesium deficiency. Magnesium concentrates in the Muscles (26% of the body’s total Magnesium is stored in Muscles) - the role of Magnesium in the Muscles is to ensure that sufficient Oxygen is delivered to the Muscles. Magnesium is also required for Muscle movement and for the transmission of Nerve Impulses to the Muscles.
Magnesium may alleviate Muscular Tics (by improving the electric conductance of Nerve Impulses at the junctions between the Nerves and Muscles) and Magnesium deficiency may be the underlying cause of Muscular Tics:
- - Blepharospasm (Tics of the Eyelids) may occur as a result of Magnesium deficiency (and supplemental Magnesium may alleviate Blepharospasm where Magnesium deficiency is the cause of Blepharospasm).
Magnesium may alleviate Bruxism.
Magnesium may alleviate Periodontal Disease (by increasing the density of Alveolar Bone).
Magnesium may harden Teeth and may prevent Tooth Decay (by stimulating the formation of Tooth Enamel):
- - 1% of the body's Magnesium is concentrated in the Teeth.
Asthma may occur as a result of Magnesium deficiency:
- - Magnesium may reduce the bronchoconstriction associated with Asthma by relaxing the (Smooth) Muscle around the bronchial tubes.
- - Intravenous solutions containing Magnesium may successfully break acute Asthma attacks.
Chronic Obstructory Pulmonary Disease (COPD) patients are often found to have low (muscle but not serum) levels of Magnesium. Globus Sensation (a sensation of Throat constriction) may occur as a result of Magnesium deficiency.
Magnesium may improve the function of the Lungs:
- - In one study, subjects who consumed at least 380 mg of Magnesium per day exhibited superior Lung function compared to those consuming less than 380 mg of Magnesium per day regardless of whether the subjects smoked or not.
Magnesium (400 - 1,000 mg per day) may alleviate Dysmenorrhea (especially when Magnesium is administered together with Vitamin B6).
Magnesium may alleviate Mastalgia (breast Pain) where Mastalgia is associated with Pre-Menstrual Syndrome (PMS).
Menstruation may cause the depletion of Magnesium.
Women who experience Morning Sickness are often found to have abnormally low Magnesium levels, indicating that Magnesium deficiency may contribute to Morning Sickness.
Magnesium may alleviate the Irritability, Fatigue, Depression and Edema associated with Pre-Menstrual Syndrome (PMS) - especially the PMS-C (Cravings) form of PMS.
Magnesium may alleviate the Muscle Cramps (leg Cramps) that often occur during Pregnancy and may prevent/treat Preeclampsia.
Magnesium deficiency may cause Premature Ejaculation.
Prostate disorders may occur as a symptom of Magnesium deficiency.
Water & Water Balance
Edema may occur as a result of Magnesium deficiency.
MAGNESIUM – DOSAGE RECOMMENDATIONS Introduction
This section outlines the body’s requirement for Magnesium and therapeutic dosages for suppemental Magnesium.
Prevalence of Magnesium Deficiency
Up to 75% of the population are Magnesium deficient - Magnesium deficiency (called hypomagnesemia) is one of the most common dietary deficiencies in the world - especially in elderly people:
- - 39% of adults in the USA consume less than 66% of the RDA for Magnesium.
Balancing Magnesium with other Minerals
Supplemental Magnesium should be taken at a different time of the day to supplementary Calcium (as Calcium prevents the absorption of Magnesium if it is consumed in conjunction with Magnesium).
Human Body Magnesium Content
The Magnesium content of body of a person of average weight is 30 - 35 grams (this equates to 0.05% of body weight).
Average Dietary Intake
The average Western dietary intake of Magnesium is 200 mg per day for women and 240 mg per day for men.
The average Asian and vegetarian dietary intake of Magnesium is 500 - 700 mg per day.
Recommended Dietary Intake
The most common RDA for Magnesium is 300 mg per day for women and 350 mg per day for men.
Therapeutic Magnesium Dosages
General Optimal Therapeutic Dosage
The optimal daily allowance (ODA) of Magnesium (for adults) is 500 - 1,000 mg per day (depending on weight):
- - The precise therapeutic dosage is 6 - 10 mg of Magnesium per kg of body weight (2.7 - 4.53 mg per pound of body weight).
- - Assuming that dietary sources of Magnesium supply 3.3 mg of Magnesium per kg of body weight (1.5 mg per pound of body weight), the supplemental dosage of Magnesium (from capsules/tablets or powders) would be 2.7 - 6.7 mg of Magnesium per kg of body weight.
- - Based on these assumptions the following table lists the dosage of supplemental Magnesium required to reach a total daily intake of approximately 6 - 10 mg per kg of body weight:
The therapeutic dosage of Magnesium for the treatment of Alzheimer’s Disease is 1,000 mg per day.
The therapeutic dosage of Magnesium for the treatment of Pre-Menstrual Syndrome (PMS) is 500 - 1,000 mg per day.
General Usage Considerations
The absorption of Magnesium decreases rapidly when more than 200 mg is consumed at one time - it is therefore advisable to take Magnesium supplements in divided doses during the day.
Form of Magnesium Supplementation
Many of the therapeutic benefits associated with Magnesium are optimized when Magnesium is consumed as Magnesium Aspartate and combined with Potassium Aspartate.
Toxic Magnesium Levels
Magnesium’s toxic effects do not usually occur unless a plasma Magnesium level of 3.5 - 5.0 mmol/L is reached.
Magnesium Must be Properly Balanced with these Minerals
The body should contain twice the amount of Calcium as Magnesium, i.e. the Calcium:Magnesium ratio is 2:1.
High dietary levels of Phosphorus inhibit the body’s absorption of Magnesium.
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