"Hawaii in a bottle". A direct precursor for the neurotransmitter serotonin (the "feel good" hormone). 5-HTP has profound mood-lifting effects and is as effective as the best anti-depressant drug (but without side effects). It promotes healthy sleep wake patterns and emotional stability. It assists with migraines, reduces appetite and alleviates anxiety.
Also known as: 5-Hydroxytryptophan
5-HTP is an endogenous, intermediate Amino Acid formed from Tryptophan. Exogenous 5-Hydroxytryptophan is manufactured as a supplement as a means of bypassing the first step in the production of endogenous Serotonin.
Health Benefits of Supplemental 5-HTP
5-HTP possesses Antioxidant properties.
5-HTP may reduce appetite in persona afflicted with obesity.
5-HTP (50 - 300 mg per day) may alleviate Fibromyalgia.
5-HTP may reduce aggressiveness (without decreasing Assertiveness). 5-HTP may alleviate anxiety. 5-HTP may reduce appetite in persons afflicted with obesity 5-HTP may reduce Carbohydrate Cravings (due to 5-HTP’s role in the production of Serotonin). 5-HTP may increase assertiveness (non-aggressive assertiveness). 5-HTP may be beneficial for attention deficit/hyperactivity disorder (ADHD)(due to its role as a precursor for the production of Serotonin, a Neurotransmitter that is commonly depleted in ADD patients). 5-HTP may alleviate various forms of depression (including endogenous depression, major depression and reactive depression). 5-HTP may be a valuable adjutant therapy for Down’s syndrome. 5-HTP may be a valuable adjutant therapy for Epilepsy. 5-HTP may prevent headaches (especially tension headaches). 5-HTP may alleviate insomnia. 5-HTP prevents and alleviates the symptoms of migraines.
5-HTP may improve mood (due to its ability to increase Serotonin levels):
5-HTP may induce feelings of happiness (described as elation). 5-HTP (50 - 200 mg per day) may be an effective treatment for obsessive-compulsive disorder (OCD) (according to anecdotal reports). 5-HTP may alleviate panic disorder.
5-HTP may be a useful adjuvant therapy for Parkinson’s disease.
5-HTP may enhance the Function of these Substances
5-HTP may increase Brain Melatonin levels (via Serotonin and N-Acetyl-Serotonin).
5-HTP is the immediate metabolic precursor for endogenous Serotonin.
5-HTP may increase Beta-Endorphin levels (especially in Depression patients).
These Substances may enhance the Function of 5-Hydroxytroptophan
5-HTP is manufactured within the body from Tryptophan.
The 5-HTP Decarboxylase enzyme catalyzes the conversion of 5-Hydroxytryptophan to Serotonin (5-HT).
The Tryptophan Hydroxylase enzyme catalyzes the conversion of Tryptophan to 5-Hydroxytryptophan.
Vitamin B6 is a co-factor for the endogenous conversion of 5-Hydroxytryptophan to Serotonin via the 5-HTP Decarboxylase enzyme.
Vitamin C is an essential co-factor for the conversion of Tryptophan to 5-HTP.
These Herbs may Enhance the Function of 5-HTP
Golden Root may facilitate the transport of 5-HTP into the Brain.
Potentially Toxic Effects of 5-HTPDigestive System:
Supplemental 5-HTP may cause diarrhoea in some persons.
Supplemental 5-HTP may cause intestinal cramps in some persons.
Supplemental 5-HTP may cause nausea in some persons.
Comparison of Selective Serotonin Reuptake Inhibitors (SSRIs) with 5-HTP
SSRIs "work" by counteracting deficiency in the Neurotransmitter, Serotonin. They increase available Serotonin by preventing Serotonin Receptors from soaking up recently released molecules of Serotonin "floating" around freely in the Synapses between Neurons (inhibiting reuptake).
In contrast, Tryptophan is a precursor for the production of NEW Serotonin. This is regarded as a superior method of treating Serotonin deficiency compared to the modus operandi of SSRIs, which merely recycle OLD Serotonin.
5-HTP vs. Tryptophan
5-HTP is a direct precursor for Serotonin. It is approximately ten times more potent on a gram for gram basis for the production of Serotonin.
Unlike Tryptophan, serotonin synthesis from 5-HTP is not rate-limited by any natural feedback control for Serotonin synthesis. 5-HTP bypasses this governing mechanism. This permits 5-HTP to significantly increase Serotonin production by also increases the potential for excessive Serotonin synthesis.
5-HTP is unaffected by the Tryptophan Pyrrolase (TP) enzyme and is therefore fully available for Serotonin synthesis.
Tryptophan is a precursor for Serotonin but is two metabolic steps away from Serotonin.
Serotonin synthesis from Tryptophan is rate-limited by a natural feedback control for Serotonin synthesis. This may be useful for preventing excessive Serotonin production.
High doses of Tryptophan cause its own destruction by inducing the enzyme, Tryptophan Pyrrolase (TP) which metabolizes Tryptophan to Kynurenine.
5 -HTP cannot be used by the body for the production of proteins and enzymes.
Tryptophan is used by the body for purposes other than Serotonin production. It can be used for the creation of certain proteins and enzymes.
5-HTP is NOT a precursor for the production of NADH.
Tryptophan is a precursor to NADH.
5-HTP does not aggravate pre-existing bacterial and parasitic infections.
Sometimes supplemental Tryptophan can aggravate pre-existing bacterial and parasitic infections.
5-HTP readily crosses the Blood-Brain Barrier.
Endogenous 5-HTP Levels.
Laboratory Reference Values.
Orally administered 5-HTP is well absorbed - approximately 70% of orally ingested 5-HTP enters the bloodstream.
Absorption of supplemental 5-HTP is maximized when it is consumed orally two to three hours after a meal (or on an empty Stomach) and at least 30 to 60 minutes prior to the following Protein-containing meal:
- The conversion of 5-HTP to Serotonin (in the Brain) can be maximized by taking supplemental 5-HTP on an empty Stomach (or more specifically, without Protein-containing foods).
The duration of action of 5-HTP is relatively short. For this reason, the therapeutic effects of supplemental.
5-HTP may be maximized if it is taken as several divided doses instead of one full dose.
Most orthomolecular-oriented physicians recommend the use of 300 - 600 mg of 5-HTP per day for the treatment of depression:
- Many people using 5-HTP for the treatment of depression experience benefits from doses of 50 - 150 mg per day and some people experience benefit from as little as 25 mg of 5-HTP per day.
The standard dosage of 5-HTP for the treatment of Epilepsy is 150 - 300 mg per day.
The standard dosage of 5-HTP for the treatment of Down’s Syndrome is 1 mg of 5-HTP per kg of body weight.
The standard dosage of 5-HTP for the treatment of Parkinson’s Disease is 100 - 600 mg per day.
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