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Product Information Quercetin is a potent Antioxidant and assists with cataracts, inflammation, allergies and has significant anti-tumor activity against various forms of Cancer. It prevents many infections caused by viruses and helps to suppress the HIV virus, Epstein-Barr virus, and Herpes Simplex Virus and many strains of Influenza Viruses. Alleviates the Common Cold, lowers total serum Cholesterol levels and the oxidation of LDL Cholesterol. Assists with Diabetes complications. Helps to prevent Cataracts in Diabetes, alleviates Gout and Rheumatoid Arthritis, Asthma, Hay Fever, Sinusitis, Prostatis. Enhances the secretion of Insulin, protects the body's endogenous (DNA) by chelating (removing) Ferric Iron from the body. Quercetin recycles Glutathione. Helps to protect against Cardiovascular Diseases and prevents Strokes.
PROPRIETARY NAME (and dosage form): Quercetin (capsules) COMPOSITION: Each capsule contains the following as active ingredients: Quercetin........................................................400mg With Bromelain for enhanced absorption Inactive ingredients: Hypromellose (cellulose) vegetarian capsule shell (gelatin free), microcrystalline cellulose, magnesium stearate (vegetarian – flow agent), magnesium silicate, silicon dioxide and colloidal silicon dioxide. Contains no colourants, preservatives, lactose, gluten, yeast, starch or artificial fillers. Contains plant extracts and natural fillers, with no colourants added - therefore the colour of the capsule contents may vary slightly from batch to batch. PHARMACOLOGICAL ACTION: Quercetin is a flavonoid that occurs in red wine, green tea, onions, tomatoes, broccoli, green beans, asparagas, apples and berries. Dietery quercetin glycosides are hydrolyzed in the intestine to produce the aglycone, and also undergo deglycosidation by enterobacteria. The aglycone in then conjugated to glucuronides or sulphates for absorption. Quercetin is present in the plasma glucuronides, sulphates and O-methylated derivatives, with only small quantities of the aglycone. Quercetin has anti-oxidant, anti-inflammatory, anticarcinogenic, and cardioprotective effects. The anti-oxidant effect is attributed to the cathechol-B-ring and the location of the hydroxyl substitutions. The anti-oxidant effect is due to its being able to be converted to substances that release reactive oxygen species. The anti-inflammatory effects of quercetin is due to its inhibition of the production and activity of leukotrienes and prostaglandins, and inhibition of histamine release by basophils and mast cells. Animal studies indicate that quercetin inhibits cox-2 enzymes and also NF-kB which controls expression of genes encoding pro-inflammatory cytokines. Quercetin has demonstrated activity against retroviruses, herpes simplex, polio, parainfluenza and respiratory syncytial viruses. This is attributed to quercetin’s ability to reduce the infectivity of viruses and block viral replication. Quercetin has also been shown to have a positive effect on the human immune system. Possibly by increasing neutrophil chemotaxis, macrophage phagocytosis, natural killer cell lytic activity, and mitogen-stimulated lymphocyte proliferation. Quercetin’s anticarcinogenic effects have been attributed to the following mechanisms, anti-oxidant effects, inhibition of cell proliferation, cell cycle arrest, induction of apoptosis, promotion of cell differentiation, and inhibition of angiogenesis. Quercetin has also been shown to have anti-allergy effects attributed to the fact that it may affect mast cell proliferation and secretory granule development. Quercetin consumption exhibited an inhibitory effect on the development of aortic artherosclerotic lesions and on arthrogenic modifications of LDL injury by inhibiting lipoprotein oxidation or by directly protecting cells from oxidized low density lipoproteins. Pharmacokinetics: The time to maximum plasma concentrations (Tmax) after oral administration of quercetin aglycone is dose-dependent. After an oral dose of 8, 20, or 50 mg, Tmax is 1.9, 2.7, or 4.9 hours, respectively. The half-lives of quercetin and its metabolites range from 11-28 hours. Quercetin is excreted in the urine as glucuronide and sulphate derivatives. INDICATIONS: Quercetin is a flavonoid extracted from fruit. It supports a healthy immune function and has anti-allergy, anti-cancer and anti-viral effects. Quercetin also reduces the risk of death from coronary artery disease. Ordinary quercetin is not well absorbed from the intestine. However bromelain enzymes have been added to improve its absorption. CONTRA-INDICATIONS: There are no known contra-indications. WARNINGS: Do not exceed recommended dosages unless on the advice of a healthcare provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. INTERACTIONS: Cyclosporin: Quercetin increases plasma levels and prolongs the half-life of cyclosporin. Cytochrome P450 2C8, 2C9, 2D6, 3A4: Preliminary evidence indicated that quercetin inhibits these enzymes and this may lead to reduced elimination and higher plasma levels of medicines metabolised by these substrates. Some medicines that could be affected include: amiodarone, docetaxel, tretinoins, repaglinide, verapamil, celecoxib, diclofenac, fluvastatin, glipizide, ibuprofen, irbesartan, losartan, phenytoin, piroxicam, tamoxifen, tolbutamide, torsemide, warfarin, amitriptyline, codeine, flecainide, haloperidol, imipramine, metoprolol, ondansetron, paroxetine, risperidone, tramadol, venlafaxine, calcium channel blockers, chemotherapeutic agents antifungals, glucocorticoids, alfentanil, fentanyl, losartan, fluoxetine, midazolam, omeprazole, lansoprazole, propranolol, fexofenadine, amitriptyline, amiodarone, citalopram, sertraline and numerous others. P-Glycoprotein substrates: There is preliminary evidence that the quercetin inhibits the gastrointestinal P-glycoprotein efflux pump. This may increase the bioavailability and the serum levels of drugs transported by the pump. Medicines transported by the pump include: paclitaxel, diltiazem, cyclosporine, saquinavir, digoxin, chemotherapeutic agents (etoposide, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir), H2 antagonists (cimetidine, ranitidine), verapamil, corticosteroids, erythromycin, fexofenadine, loperamide, quinidine, and others. Quinolone antibiotics: Quercetin might competitively inhibit quinolone antibiotics by binding to the DNA gyrase site on bacteria. Quinolones include: ciprofloxacin, levofloxacin , ofloxacin, moxifloxacin, gatifloxacin and others. PREGNANCY AND BREAST-FEEDING: Safety in pregnancy and breast-feeding has not been established, do not use. DOSAGE AND DIRECTIONS FOR USE: Adults and children over 12 years of age: Take 1 capsule twice daily with meals. This dose can be doubled under the advice of a healthcare provider. Children under 12 years of age: Take half the adult dose. SIDE EFFECTS AND SPECIAL PRECAUTIONS: Side effects: The following side effects have been reported: Headache, allergy, gastro-intestinal upset and tingling of the extremities. Doses exceeding 6 capsules per day may be damaging to the kidney. Special precautions: Pineapple allergy: Individuals allergic to pineapples should use caution, as bromelain is made from pineapples. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: Treatment should be symptomatic and supportive. In the case of accidental overdose of the product, contact the nearest hospital or poison control centre. IDENTIFICATION: Clear vegetarian capsule shell (size 0) containing light yellow contents. PRESENTATION: White HDPE container with white HDPE screw cap and seal for protection. STORAGE INSTRUCTIONS: Store in a cool dry place, out of the reach of children.
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