Voted 1 of the top 12 Anti Aging Supplements by the Life Extension Foundation, USA. The most effective homocysteine-lowering agent is Trimethylglycine (TMG). Homocysteine Accelerates Aging, according to the Life Extension Foundation USA. Health benefits of TMG include, prevention of Cardiovascular Disease, improves Athletic Performance by improving the body's Energy levels, increasing Stamina and improving the body's utilization of Oxygen. Increases the body's Energy levels and assists the Liver's efficiency in metabolizing Fatty Acids. TMG detoxifies and stimulates the Liver.
Also known as: Anhydrous Betaine; Glycine Betaine; Glycyl Betaine; Oxyneurine; TMG; Trimethylglycine; Trimethylglycocoll Anhydride
Betaine is a type of Alkaloid that functions as a methyl donor.
Health Benefits of Betaine
Betaine (especially the Trimethylglycine (TMG) form of Betaine) helps to prevent Cardiovascular Diseases (due to Betaine functioning as a methyl donor which lowers Homocysteine levels).
Betaine Hydrochloride may reduce the risk of Gallstones in persons with low levels of Hydrochloric Acid (i.e. in persons afflicted with Hypochlorhydria).
Betaine Hydrochloride alleviates many cases of Heartburn (by increasing the level of Hydrochloric Acid in the Stomach).
Supplemental Betaine Hydrochloride (2 ml diluted in 200 ml Water and sipped through a straw to avoid contact with the Teeth) functions as a supplemental source of Hydrochloric Acid for Hypochlorhydria patients.
Betaine improves Athletic Performance (by improving the body’s Energy levels, increasing Stamina and improving the body’s utilization of Oxygen).
Betaine increases the body’s Energy levels.
Betaine increases the Liver's efficiency in metabolizing Fatty Acids.
Betaine reduces Homocysteine levels (during its metabolism within the body, Betaine transfers one of its Methyl Groups to Homocysteine, causing Homocysteine to be converted to Methionine; Betaine, by losing one methyl group becomes Dimethyl Glycine (DMG)).
Betaine detoxifies and stimulates the Liver:
- Betaine helps to prevent and reverse Fatty Liver.
Betaine improves the body’s utilization of Oxygen.
Betaine increases Stamina.
Betaine improves the behavior and Mental Function of children afflicted with Down’s Syndrome (this improvement is due to Betaine functioning as a methyl donor).
Betaine Enhances the Function of these Substances
Betaine (especially the Trimethylglycine (TMG) form of Betaine) increases S-Adenosylmethionine (SAM) levels.
Dietary (or supplemental) Betaine increases the activity of the Betaine-Homocysteine Methyltransferase (BHMT) enzyme.
Betaine (Betaine Hydrochloride form only) facilitates the absorption of Folic Acid.
Betaine Counteracts these Toxic Substances
Betaine (especially the Trimethylglycine (TMG) form of Betaine) lowers elevated Homocysteine levels.
Betaine (especially the Trimethylglycine (TMG) form of Betaine) helps to prevent Alcohol (ethanol)-induced Fatty Liver.
These Substances Enhance the Function of Betaine
The Betaine-Homocysteine Methyltransferase (BHMT) enzyme catalyzes the conversion of Betaine (together with Homocysteine) to Dimethyl Glycine (DMG) and Methionine.
Choline Oxidase catalyzes the conversion of Choline to Betaine Aldehyde and subsequently catalyzes the conversion of Betaine Aldehyde to Betaine.
Betaine can be manufactured within the body as a degradation by-product of Choline (via the Choline Oxidase Enzyme).
Dietary Sources of Betaine
Herbs: Astragalus Cola
Vegetables: Beetroot Broccoli
Betaine Hydrochloride (Betaine HCl) consists of 76% Betaine combined with 24% Hydrochloride (HCl). It is used as a supplemental form of Hydrochloric Acid. Some ers have stated that Betaine Hydrochloride does not provide the therapeutic effects attributable to pure Betaine (Trimethylglycine).
Trimethylglycine (TMG) is 100% Betaine and is purported to be the optimum form of Betaine for all uses other than correcting Hydrochloric Acid deficiency.
The preventative dosage of the Trimethylglycine (TMG) form of Betaine commonly used by healthy people to prevent Cardiovascular Diseases is 500 mg per day.
A dosage of 2,000 - 6,000 mg (2 - 6 grams) per day of the Trimethylglycine (TMG) form of Betaine is commonly recommended for people with pre-existing Cardiovascular Disease.
When the Betaine Hydrochloride form of Betaine is used for the correction of Hydrochloric Acid deficiency (Hypochlorhydria), the usual dosage is 325 - 800 mg taken with each meal (a total of 975 - 2,400 mg per day).
A dosage of 2,000 - 4,000 mg (2 - 4 grams) per day of the Trimethylglycine (TMG) form of Betaine is commonly recommended for people with pre-existing Liver Disease.
Following its ingestion, Betaine is converted to Dimethyl Glycine (DMG) within the Liver.